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<p>Gamma-hydroxybutyrate (GHB) is a central nervous system depressant with a high potential for dependence. Withdrawal can be severe and potentially life-threatening, often necessitating medical intervention. Evidence on outpatient detoxification remains limited. We present a case of a 41-year-old woman with severe GHB dependence to illustrate a structured, safe outpatient detoxification approach. This consisted of a gradual GHB tapering over 27&#xa0;days, supported by adjunctive pharmacotherapy and intensive clinical monitoring. She achieved abstinence at the end of the tapering regime and has maintained recovery for 7&#xa0;months to date. This case illustrates that outpatient detoxification can be feasible in carefully selected patients, whilst highlighting the need for standardised protocols and further research to optimise treatment strategies.</p>

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A Case Study Showing a Pharmacologic Approach to Gamma-Hydroxybutyrate (GHB) Detoxification in the Community

  • 期刊论文

  • 发表日期：

    2025年11月11日

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  • Jonas Muscat,
  • Kristian Sant

摘要

Gamma-hydroxybutyrate (GHB) is a central nervous system depressant with a high potential for dependence. Withdrawal can be severe and potentially life-threatening, often necessitating medical intervention. Evidence on outpatient detoxification remains limited. We present a case of a 41-year-old woman with severe GHB dependence to illustrate a structured, safe outpatient detoxification approach. This consisted of a gradual GHB tapering over 27 days, supported by adjunctive pharmacotherapy and intensive clinical monitoring. She achieved abstinence at the end of the tapering regime and has maintained recovery for 7 months to date. This case illustrates that outpatient detoxification can be feasible in carefully selected patients, whilst highlighting the need for standardised protocols and further research to optimise treatment strategies.