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<p>This research introduces a hybrid quantum dot (QD)–plasmonic photonic crystal fiber (PCF) biosensor with a dual-mode functioning to detect multiple biomarkers in a very selective manner at high sensitivity. The sensor couples QDs with an internally metalized PCF structure and thus a strong exciton–plasmon coupling system is formed, which enhances the confinement of the electric field and the detection’s precision. The rate-equation modeling-based FEM simulations confirm the strong coupling with the Rabi splitting energy of 126 meV at the optimal QD layer thickness of 12&#xa0;nm. The maximum wavelength sensitivity of the sensor is 460&#xa0;nm/RIU, the figure of merit (FOM) is 35.4, and the limit of detection is 8.0 × 10⁻⁵ RIU, which corresponds to approximately 0.45 pg/mm² mass sensitivity for COVID-19 spike protein detection. It is able to separate analytes with index values ranging between 1.33 and 1.42 efficiently and it is highly time stable such that it can be followed continuously. The novelty of this study is based on the inner metalized QD-plasmonic design where the ability to operate the dual-mode is not only by combining the plasmonic and excitonic resonances but also due to reduced false positive and increased selectivity. Generally, the offered hybrid PCF biosensor is one of the possible solutions to the future extraction of real-time and multi-biomarker biomedical diagnostics.</p> Graphical Abstract <p></p>

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Quantum Dot-Assisted Hybrid Plasmonic Photonic Crystal Fiber Biosensor for Ultra-Sensitive Multi-Biomarker Detection in Personalized Healthcare

  • 期刊论文

  • 发表日期：

    2025年12月18日

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  • Manjunathan Alagarsamy,
  • Premalatha Gurumurthy,
  • Vairaprakash Selvaraj,
  • Srinidhi Sundaram,
  • G. K. Kamalam,
  • M. Ameena Banu,
  • S. Kanimozhi,
  • K. Deepa

摘要

This research introduces a hybrid quantum dot (QD)–plasmonic photonic crystal fiber (PCF) biosensor with a dual-mode functioning to detect multiple biomarkers in a very selective manner at high sensitivity. The sensor couples QDs with an internally metalized PCF structure and thus a strong exciton–plasmon coupling system is formed, which enhances the confinement of the electric field and the detection’s precision. The rate-equation modeling-based FEM simulations confirm the strong coupling with the Rabi splitting energy of 126 meV at the optimal QD layer thickness of 12 nm. The maximum wavelength sensitivity of the sensor is 460 nm/RIU, the figure of merit (FOM) is 35.4, and the limit of detection is 8.0 × 10⁻⁵ RIU, which corresponds to approximately 0.45 pg/mm² mass sensitivity for COVID-19 spike protein detection. It is able to separate analytes with index values ranging between 1.33 and 1.42 efficiently and it is highly time stable such that it can be followed continuously. The novelty of this study is based on the inner metalized QD-plasmonic design where the ability to operate the dual-mode is not only by combining the plasmonic and excitonic resonances but also due to reduced false positive and increased selectivity. Generally, the offered hybrid PCF biosensor is one of the possible solutions to the future extraction of real-time and multi-biomarker biomedical diagnostics.

Graphical Abstract