Scholarlink

<p>Colorectal cancer remains a leading cause of cancer-related mortality worldwide, underscoring the urgent need for novel, effective, and sustainable treatment strategies. Here, we report a facile, eco-friendly synthesis of silver-decorated magnesium oxide nanoparticles using <i>Rumex acetosa</i> extract (<i>RAE</i>@MgO/Ag NPs) as a natural reducing and stabilizing agent. X-ray Diffraction (XRD) confirmed the successful formation and crystallinity of the MgO/Ag NPs, while Fourier transform infrared spectroscopy (FT-IR), Energy-dispersive X-ray spectroscopy (EDS), and Field emission scanning electron microscopy (FESEM) verified phytochemical capping, uniform composition, and spherical morphology. FT-IR spectra indicated the incorporation of plant-derived constituents on the nanoparticle surface, which may contribute to enhanced bioactivity. The anticancer potential of <i>RAE</i>@MgO/Ag was evaluated against the HT-29 human colorectal cancer cell line and showed significantly higher cytotoxicity (IC<sub>50</sub> = 481.5&#xa0;µg/mL) compared with both bare MgO and chemically synthesized Ag-decorated MgO (Ch-MgO/Ag). These findings highlight the therapeutic promise of biogenic <i>RAE</i>@MgO/Ag nanoparticles and reinforce the value of green nanotechnology in developing next-generation anticancer agents.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Potent Cytotoxic Activity Against Human Colorectal Cancer Cells by Biogenic Silver-Decorated MgO Nanoparticles

  • 期刊论文

  • 发表日期：

    2025年9月30日

查看全文
  • Sepide Mahmoudi Berneti,
  • Elham Chamani,
  • Yasaman Soleimanmanesh,
  • Pouria Mohammadparast-Tabas,
  • Parisa Kadkhoda,
  • Sobhan Mortazavi-Derazkola

摘要

Colorectal cancer remains a leading cause of cancer-related mortality worldwide, underscoring the urgent need for novel, effective, and sustainable treatment strategies. Here, we report a facile, eco-friendly synthesis of silver-decorated magnesium oxide nanoparticles using Rumex acetosa extract (RAE@MgO/Ag NPs) as a natural reducing and stabilizing agent. X-ray Diffraction (XRD) confirmed the successful formation and crystallinity of the MgO/Ag NPs, while Fourier transform infrared spectroscopy (FT-IR), Energy-dispersive X-ray spectroscopy (EDS), and Field emission scanning electron microscopy (FESEM) verified phytochemical capping, uniform composition, and spherical morphology. FT-IR spectra indicated the incorporation of plant-derived constituents on the nanoparticle surface, which may contribute to enhanced bioactivity. The anticancer potential of RAE@MgO/Ag was evaluated against the HT-29 human colorectal cancer cell line and showed significantly higher cytotoxicity (IC50 = 481.5 µg/mL) compared with both bare MgO and chemically synthesized Ag-decorated MgO (Ch-MgO/Ag). These findings highlight the therapeutic promise of biogenic RAE@MgO/Ag nanoparticles and reinforce the value of green nanotechnology in developing next-generation anticancer agents.