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<p>A highly sensitive D-type photonic crystal fiber (PCF) sensor based on surface plasmon resonance (SPR) is proposed for the detection of cancer cells through refractive index (RI) monitoring. The sensor features a semicircular groove on the polished surface, coated with dual layers of gold (Au) and titanium dioxide (TiO₂) to enhance plasmonic coupling. Finite element method (FEM) analysis shows that the sensor has a refractive index range, maximum wavelength sensitivity, and resolution of 1.355–1.395, 54,000&#xa0;nm/RIU, and 1.85 × 10<sup>−6</sup> RIU, respectively, boding well for the early screening of cancer cells with a sensitivity in the range of 2500–24,285&#xa0;nm/RIU. The compact sensor comprising a standard single-mode fiber with an outer diameter of 125&#xa0;μm can be produced easily and has large application prospects in fields such as biomedical diagnosis, disease screening, and environmental detection.</p>

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Ultra-sensitive D-Type PCF-SPR Biosensor with Dual-layer Au/TiO₂ Coating for Early Cancer Cell Detection

  • 期刊论文

  • 发表日期：

    2025年7月23日

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  • Yuan Sun,
  • Jingwei Lv,
  • Famei Wang,
  • Wei Liu,
  • Jianxin Wang,
  • Zao Yi,
  • Miao Liu,
  • Qiang Liu,
  • Paul K. Chu,
  • Chao Liu

摘要

A highly sensitive D-type photonic crystal fiber (PCF) sensor based on surface plasmon resonance (SPR) is proposed for the detection of cancer cells through refractive index (RI) monitoring. The sensor features a semicircular groove on the polished surface, coated with dual layers of gold (Au) and titanium dioxide (TiO₂) to enhance plasmonic coupling. Finite element method (FEM) analysis shows that the sensor has a refractive index range, maximum wavelength sensitivity, and resolution of 1.355–1.395, 54,000 nm/RIU, and 1.85 × 10−6 RIU, respectively, boding well for the early screening of cancer cells with a sensitivity in the range of 2500–24,285 nm/RIU. The compact sensor comprising a standard single-mode fiber with an outer diameter of 125 μm can be produced easily and has large application prospects in fields such as biomedical diagnosis, disease screening, and environmental detection.