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<p>The present work is based on the synthesis of the multifunctional nanocomposites by introducing the laser synthesized silver (Ag), zinc oxide (ZnO), and Ag@ZnO nanoparticles (NPs) into polycaprolactone (PCL) and polylactic acid (PLA) matrix. Nanoparticles were prepared by fiber laser ablation using 1064&#xa0;nm wavelength, 127&#xa0;ns pulse duration, 30&#xa0;kHz repetition rate, 100&#xa0;µm beam spot, 100&#xa0;mm focal length, 8.9&#xa0;J/cm<sup>2</sup> laser fluence, 200&#xa0;mm/s scanning speed, and 3&#xa0;min irradiation time. Then, the prepared NPs were incorporated into the polymer host. The composites were evidenced by UV–Vis spectroscopy, EDS/EDX, FTIR, SEM and TEM, to assess the composition and structure, morphological appearance. The SEM and TEM results indicated that the porosity and roughness of nanomaterials enhanced after the nanoparticle mixing, which might have a positive effect on the biological interactions. EDS mapping was used to verify the even dispersion of nanoparticles; the composition of the crystalline element was also identified by the EDX profile. UV–Vis characterization confirmed the improved optical properties and shift of the peak in the samples with the presence of Ag and ZnO. The nanocomposites possessed significant antibacterial activity against <i>Staphylococcus aureus</i> (<i>S. aureus</i>), and the inhibition zones increased with the concentration of nanoparticles. Cytotoxicity studies indicated a remarkable anticancer activity against lung cancer cell line A549. In terms of mechanical properties, the ZnO + PCL samples were more ductile, while the Ag@ZnO + PLA composites exhibited greater tensile strength and stiffness. These findings highlight the versatility of laser-fabricated nanocomposites as an easily tailored platform for biomedical applications including wound healing, antimicrobial barriers, tissue engineering scaffolds.</p>

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A Study of the Mechanical and Biological Properties of Laser-Generated Nanocomposite Materials

  • 期刊论文

  • 发表日期：

    2025年8月19日

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  • Alaa Al-Taie,
  • Fatema H. Rajab,
  • Rana M. Taha,
  • Humam Abdulrahman Ibrahim,
  • Salim Albukhaty,
  • Majid S. Jabir,
  • Suresh Ghotekar,
  • Muhammad Faheem Akhtar,
  • Ayman A. Swelum

摘要

The present work is based on the synthesis of the multifunctional nanocomposites by introducing the laser synthesized silver (Ag), zinc oxide (ZnO), and Ag@ZnO nanoparticles (NPs) into polycaprolactone (PCL) and polylactic acid (PLA) matrix. Nanoparticles were prepared by fiber laser ablation using 1064 nm wavelength, 127 ns pulse duration, 30 kHz repetition rate, 100 µm beam spot, 100 mm focal length, 8.9 J/cm2 laser fluence, 200 mm/s scanning speed, and 3 min irradiation time. Then, the prepared NPs were incorporated into the polymer host. The composites were evidenced by UV–Vis spectroscopy, EDS/EDX, FTIR, SEM and TEM, to assess the composition and structure, morphological appearance. The SEM and TEM results indicated that the porosity and roughness of nanomaterials enhanced after the nanoparticle mixing, which might have a positive effect on the biological interactions. EDS mapping was used to verify the even dispersion of nanoparticles; the composition of the crystalline element was also identified by the EDX profile. UV–Vis characterization confirmed the improved optical properties and shift of the peak in the samples with the presence of Ag and ZnO. The nanocomposites possessed significant antibacterial activity against Staphylococcus aureus (S. aureus), and the inhibition zones increased with the concentration of nanoparticles. Cytotoxicity studies indicated a remarkable anticancer activity against lung cancer cell line A549. In terms of mechanical properties, the ZnO + PCL samples were more ductile, while the Ag@ZnO + PLA composites exhibited greater tensile strength and stiffness. These findings highlight the versatility of laser-fabricated nanocomposites as an easily tailored platform for biomedical applications including wound healing, antimicrobial barriers, tissue engineering scaffolds.