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<p>This study introduces a bilaterally polished groove-shaped surface plasmon resonance (SPR) sensor based on Au-TiO<sub>2</sub> for the early detection of cancer cells. The finite element method (FEM) in COMSOL Multiphysics v6.2, which is used for simulation, provides corresponding guarantee mechanisms for accuracy, reliability, repeatability, and flexibility in both calculation and simulation. The designed sensor possesses the capability to detect the range of refractive index (RI) from 1.360 to 1.401 of six distinct types of cancer cells and normal cells, including skin cancer, blood cancer, adrenal gland cancer, cervical cancer, and breast cancer types I and II. The findings indicated that blood cell exhibited the maximum wavelength sensitivity (WS) at 37,857&#xa0;nm/RIU. At the same time, skin cancer basal cell, adrenal gland cancer PC12 cell, cervical cancer HeLa cell, breast cancer type I MDAMB231 and type II MCF7 cell demonstrated WS of 16,700&#xa0;nm/RIU, 35,000&#xa0;nm/RIU, 24,583&#xa0;nm/RIU, 27,142&#xa0;nm/RIU, and 25,714&#xa0;nm/RIU. Furthermore, the maximum resolution of the sensor can reach 2.64 × 10<sup>−6</sup> RIU for basal cell, and a FOM value of 659 for MCF7 cell. With its compact and unique PCF structure and SPR effect, the sensor can capture subtle RI changes triggered by early-stage cancer cells, detecting them at low concentrations of characteristic markers of cancer cells and dynamically tracking the early stages of cancer development, thus providing the possibility of early cancer screening.</p>

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Highly Sensitive Early Cancer Cell Detection Biosensor Based on Au-TiO 2 Coated Dual Groove PCF-SPR

  • 期刊论文

  • 发表日期：

    2025年7月26日

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  • Xing Wang,
  • Ailing Zhang,
  • Honggang Pan,
  • Qingcheng You,
  • Yukun Zhu,
  • Licui Ji,
  • Xu Gao,
  • Xinjie Zhao,
  • Yating Tang

摘要

This study introduces a bilaterally polished groove-shaped surface plasmon resonance (SPR) sensor based on Au-TiO2 for the early detection of cancer cells. The finite element method (FEM) in COMSOL Multiphysics v6.2, which is used for simulation, provides corresponding guarantee mechanisms for accuracy, reliability, repeatability, and flexibility in both calculation and simulation. The designed sensor possesses the capability to detect the range of refractive index (RI) from 1.360 to 1.401 of six distinct types of cancer cells and normal cells, including skin cancer, blood cancer, adrenal gland cancer, cervical cancer, and breast cancer types I and II. The findings indicated that blood cell exhibited the maximum wavelength sensitivity (WS) at 37,857 nm/RIU. At the same time, skin cancer basal cell, adrenal gland cancer PC12 cell, cervical cancer HeLa cell, breast cancer type I MDAMB231 and type II MCF7 cell demonstrated WS of 16,700 nm/RIU, 35,000 nm/RIU, 24,583 nm/RIU, 27,142 nm/RIU, and 25,714 nm/RIU. Furthermore, the maximum resolution of the sensor can reach 2.64 × 10−6 RIU for basal cell, and a FOM value of 659 for MCF7 cell. With its compact and unique PCF structure and SPR effect, the sensor can capture subtle RI changes triggered by early-stage cancer cells, detecting them at low concentrations of characteristic markers of cancer cells and dynamically tracking the early stages of cancer development, thus providing the possibility of early cancer screening.