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<p>Alanine aminotransferase (ALT), a critical biomarker in human blood, is strongly associated with liver injury. This study introduces a novel PCF-SPR refractive index sensor designed for the identification of ALT across various concentrations. The sensor incorporates a unique arrangement of circular air holes within the fiber structure, enhancing its optical sensing capabilities. Performance analysis was conducted employing the finite element method implemented in COMSOL Multiphysics. A thin gold layer functioning as the plasmonic material is deposited around the fiber and further stabilized with a Ta₂O₅ coating to improve adhesion between the gold and the fiber surface. Ta₂O₅ serves as both an adhesion promoter and a performance-enhancing dielectric layer, contributing to the sensor’s mechanical stability and optical performance. The sensor demonstrates reliable detection across a RI range of 1.33 to 1.42. Upon optimization of the structural parameters, the sensor achieved a peak wavelength sensitivity of 16,800.18&#xa0;nm/RIU and an amplitude sensitivity of 72.7396 RIU⁻<sup>1</sup>. Additionally, the design yielded a maximum figure of merit of 393.828. The sensor’s output showed a strong linear relationship with ALT concentration, indicating its diagnostic relevance. Under clinical evaluation conditions, the sensor attained a wavelength sensitivity of 23,474.692&#xa0;nm/RIU, amplitude sensitivity of 32.2923 RIU⁻<sup>1</sup>, and a FOM of 101.8196 RIU⁻<sup>1</sup>, confirming its potential for effective liver damage assessment.</p>

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Highly Sensitive PCF-SPR RI Sensor for ALT Detection: Clinical Application for Liver Injury Diagnosis

  • 期刊论文

  • 发表日期：

    2025年6月26日

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  • Sapana Yadav,
  • D. K. Dwivedi,
  • Pooja Lohia,
  • Yadvendra Singh

摘要

Alanine aminotransferase (ALT), a critical biomarker in human blood, is strongly associated with liver injury. This study introduces a novel PCF-SPR refractive index sensor designed for the identification of ALT across various concentrations. The sensor incorporates a unique arrangement of circular air holes within the fiber structure, enhancing its optical sensing capabilities. Performance analysis was conducted employing the finite element method implemented in COMSOL Multiphysics. A thin gold layer functioning as the plasmonic material is deposited around the fiber and further stabilized with a Ta₂O₅ coating to improve adhesion between the gold and the fiber surface. Ta₂O₅ serves as both an adhesion promoter and a performance-enhancing dielectric layer, contributing to the sensor’s mechanical stability and optical performance. The sensor demonstrates reliable detection across a RI range of 1.33 to 1.42. Upon optimization of the structural parameters, the sensor achieved a peak wavelength sensitivity of 16,800.18 nm/RIU and an amplitude sensitivity of 72.7396 RIU⁻1. Additionally, the design yielded a maximum figure of merit of 393.828. The sensor’s output showed a strong linear relationship with ALT concentration, indicating its diagnostic relevance. Under clinical evaluation conditions, the sensor attained a wavelength sensitivity of 23,474.692 nm/RIU, amplitude sensitivity of 32.2923 RIU⁻1, and a FOM of 101.8196 RIU⁻1, confirming its potential for effective liver damage assessment.