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<p>In this study, we present the design and optimization of core-gold shell nanoparticles for localized surface plasmon resonance (LSPR) biosensing. We evaluated cores made of metal alloys (Cu–Zn, Au–Ag, V-Ga), semiconductors (Si-Ge, Al-Ga-As, Ga-In-P), and inorganic oxides (ZnO, TiO₂, SiO₂). Using finite‐difference time‐domain (FDTD) simulations, all particles demonstrated strong absorption cross sections for a 10-nm gold shell and a 20-nm core radius. By calculating key performance metrics, we found that the TiO₂@Au design achieved the highest sensitivity (<i>S</i> = 130.10&#xa0;nm/RIU) and the lowest limit of detection (LoD = 7.68 × 10<sup>−7</sup> RIU), surpassing some recent literature benchmarks. The electric field enhancement was estimated for all designs, reaching a 410-fold enhancement for the TiO₂@Au design at the resonance wavelength. Moreover, when two TiO₂@Au nanoparticles are arranged as a dimer with a 2-nm gap, the hotspot field enhancement rises to approximately 3700-fold. These results provide a novel design for LSPR biosensing that can be functionalized to detect various biomarkers, including those associated with breast cancer, and pave the way for future experimental validation.</p>

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Enhancing the Performance of LSPR-Based Biosensors for Breast Cancer Diagnosis Using Core–Shell Nanoparticles

  • 期刊论文

  • 发表日期：

    2025年6月16日

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  • Chaimae El Garrab,
  • Mohssin Zekriti

摘要

In this study, we present the design and optimization of core-gold shell nanoparticles for localized surface plasmon resonance (LSPR) biosensing. We evaluated cores made of metal alloys (Cu–Zn, Au–Ag, V-Ga), semiconductors (Si-Ge, Al-Ga-As, Ga-In-P), and inorganic oxides (ZnO, TiO₂, SiO₂). Using finite‐difference time‐domain (FDTD) simulations, all particles demonstrated strong absorption cross sections for a 10-nm gold shell and a 20-nm core radius. By calculating key performance metrics, we found that the TiO₂@Au design achieved the highest sensitivity (S = 130.10 nm/RIU) and the lowest limit of detection (LoD = 7.68 × 10−7 RIU), surpassing some recent literature benchmarks. The electric field enhancement was estimated for all designs, reaching a 410-fold enhancement for the TiO₂@Au design at the resonance wavelength. Moreover, when two TiO₂@Au nanoparticles are arranged as a dimer with a 2-nm gap, the hotspot field enhancement rises to approximately 3700-fold. These results provide a novel design for LSPR biosensing that can be functionalized to detect various biomarkers, including those associated with breast cancer, and pave the way for future experimental validation.