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<p>In this systematic review, we investigate the application, benefits and drawbacks of nanomaterials in field-effect transistor (FET) biosensors. The primary objective is to evaluate the implications of nanomaterials for semiconductor technology, their implications for sensor design and how they compare to conventional sensing technologies for various applications but specifically for clinical diagnostics. We follow a standardized five-stage PRISMA methodology incorporating rigorous identification of parameters, structured selection of data and firm inclusion–exclusion parameters. Articles from freely available and Scopus-indexed journals since 2019 comprise this review. From identification and screening of many thousands of records, 93 highly relevant studies were produced from the search in Google Scholar, IEEE Xplore, Scopus and PubMed databases. The results represent the advancements in nanowire-based FET biosensors, and preparation of nanomaterials for nano-biosensing applications. Important nanomaterials (carbon nanotubes (SWCNTs and MWCNTs), graphene, silicon nanowires and magnetic nanoparticles) will be discussed and critically assessed including functionalization by different nanoparticle-based integration methods, and their implications for improvements in sensitivity, selectivity and detection limits. Current challenges (e.g. stability and reproducibility) will be highlighted as well as potential future directions for research to optimize FET biosensor technologies.</p>

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Nanomaterials for FET Biosensor–A Systematic Review on Its Application, Advantages and Limitations

  • 期刊论文

  • 发表日期：

    2025年5月26日

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  • Kavita Chaudhary,
  • Jitendra Bahadur Maurya,
  • Ankur Kumar

摘要

In this systematic review, we investigate the application, benefits and drawbacks of nanomaterials in field-effect transistor (FET) biosensors. The primary objective is to evaluate the implications of nanomaterials for semiconductor technology, their implications for sensor design and how they compare to conventional sensing technologies for various applications but specifically for clinical diagnostics. We follow a standardized five-stage PRISMA methodology incorporating rigorous identification of parameters, structured selection of data and firm inclusion–exclusion parameters. Articles from freely available and Scopus-indexed journals since 2019 comprise this review. From identification and screening of many thousands of records, 93 highly relevant studies were produced from the search in Google Scholar, IEEE Xplore, Scopus and PubMed databases. The results represent the advancements in nanowire-based FET biosensors, and preparation of nanomaterials for nano-biosensing applications. Important nanomaterials (carbon nanotubes (SWCNTs and MWCNTs), graphene, silicon nanowires and magnetic nanoparticles) will be discussed and critically assessed including functionalization by different nanoparticle-based integration methods, and their implications for improvements in sensitivity, selectivity and detection limits. Current challenges (e.g. stability and reproducibility) will be highlighted as well as potential future directions for research to optimize FET biosensor technologies.