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<p>Surface plasmon resonance (SPR) sensors are pivotal in the field of cancer diagnostics due to their high sensitivity and ability to provide real-time analysis. In this article, we aim to detect various cancer cell detection precisely based on multilayer SPR sensors utilizing silver (Ag), ferromagnetic nickel (Ni), and black phosphorus (BP) material. Ag, known for its superior plasmonic properties, significantly enhances sensitivity, while Ni improves adhesion and structural stability. Additionally, the integration of BP, with exceptional optical and electronic characteristics, increases light-matter interaction, leading to improved signal enhancement. The proposed sensor utilizes Kretschmann configuration based on Fresnel’s equation and transfer matrix method (TMM) for performance analysis. The maximum sensitivities of the distinct cancerous cells are 150.42&#xa0;deg/RIU, 204.5&#xa0;deg/RIU, 253.9&#xa0;deg/RIU, 268.4&#xa0;deg/RIU, 329.5&#xa0;deg/RIU, 412&#xa0;deg/RIU, and 397.1&#xa0;deg/RIU for colorectal cancer, skin (basal), cervical (HeLa), blood (Jurkat), adrenal gland (PC12), breast (MDA-MB-231), and breast (MCF 7) cancer, respectively. Further, the full width half maximum (FWHM), detection accuracy (DA), limit of detection (LOD), and combined sensitivity factor (CSF) have been analyzed for the proposed sensor design. Thus, the proposed SPR sensor design has the capability to detect multiple cancer cells with high precision and sensitivity. Further, the study highlights the potential of integrating 2D materials with traditional plasmonic metals to advance cancer diagnostics and provide the platform for other medical diagnostics, and environmental monitoring.</p>

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Design and Analysis of Surface Plasmon Resonance Sensor Utilizing Silver, Nickel, and Black Phosphorous for Various Cancer Detection

  • 期刊论文

  • 发表日期：

    2025年4月22日

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  • Shivangani,
  • Anupam Sahu,
  • Dharmendra Kumar,
  • Sudhanshu Verma,
  • Sudakar Singh Chauhan,
  • Rohit Kumar Tiwari,
  • Santosh Kumar

摘要

Surface plasmon resonance (SPR) sensors are pivotal in the field of cancer diagnostics due to their high sensitivity and ability to provide real-time analysis. In this article, we aim to detect various cancer cell detection precisely based on multilayer SPR sensors utilizing silver (Ag), ferromagnetic nickel (Ni), and black phosphorus (BP) material. Ag, known for its superior plasmonic properties, significantly enhances sensitivity, while Ni improves adhesion and structural stability. Additionally, the integration of BP, with exceptional optical and electronic characteristics, increases light-matter interaction, leading to improved signal enhancement. The proposed sensor utilizes Kretschmann configuration based on Fresnel’s equation and transfer matrix method (TMM) for performance analysis. The maximum sensitivities of the distinct cancerous cells are 150.42 deg/RIU, 204.5 deg/RIU, 253.9 deg/RIU, 268.4 deg/RIU, 329.5 deg/RIU, 412 deg/RIU, and 397.1 deg/RIU for colorectal cancer, skin (basal), cervical (HeLa), blood (Jurkat), adrenal gland (PC12), breast (MDA-MB-231), and breast (MCF 7) cancer, respectively. Further, the full width half maximum (FWHM), detection accuracy (DA), limit of detection (LOD), and combined sensitivity factor (CSF) have been analyzed for the proposed sensor design. Thus, the proposed SPR sensor design has the capability to detect multiple cancer cells with high precision and sensitivity. Further, the study highlights the potential of integrating 2D materials with traditional plasmonic metals to advance cancer diagnostics and provide the platform for other medical diagnostics, and environmental monitoring.