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<p>Surface plasmon resonance (SPR) sensors, which possess tunability and exceptional sensitivity, are incredibly suitable for intensive-care tension hormones like cortisol, a steroid hormone secreted by the adrenal glands in humans. The proposed sensor utilizes a Kretschmann configuration comprising BK7 prism-silver (Ag)-cadmium sulfide (CdS)-carbon nanotubes (CNTs) and sensing medium (SM), which have cortisol antibodies. The mechanism depends upon the alteration in the sensing medium’s refractive index (RI) when cortisol binds to antibody-functionalized CNTs, which shows the difference in the resonance angle. The Ag layer width has been adjusted to get SPR excitations. The sensor performance was examined by numerical simulations utilizing the transfer matrix method (TMM). Key performance factors like sensitivity (S), full width at half maximum (FWHM), quality factor (QF), limit of detection (LoD), and detection accuracy (DA) have been evaluated for different cortisol concentrations. The results demonstrate a high sensitivity of 220&#xa0;deg/RIU with QF of 60.06 RIU<sup>−1</sup> and FWHM and DA of 3.73&#xa0;deg and 0.273&#xa0;deg<sup>−1</sup>. The TMM has been utilized to perform the numerical analysis, and a plane-polarised light source with a wavelength of about 633&#xa0;nm (He–Ne laser) was employed.</p>

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Surface Plasmon Resonance-Based Cortisol Sensing: A Numerical Investigation

  • 期刊论文

  • 发表日期：

    2025年3月14日

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  • Xiuzhi Yang,
  • Harbinder Singh,
  • Arun Uniyal,
  • Shaoyong Xu,
  • Rajeev Kumar,
  • Amrindra Pal

摘要

Surface plasmon resonance (SPR) sensors, which possess tunability and exceptional sensitivity, are incredibly suitable for intensive-care tension hormones like cortisol, a steroid hormone secreted by the adrenal glands in humans. The proposed sensor utilizes a Kretschmann configuration comprising BK7 prism-silver (Ag)-cadmium sulfide (CdS)-carbon nanotubes (CNTs) and sensing medium (SM), which have cortisol antibodies. The mechanism depends upon the alteration in the sensing medium’s refractive index (RI) when cortisol binds to antibody-functionalized CNTs, which shows the difference in the resonance angle. The Ag layer width has been adjusted to get SPR excitations. The sensor performance was examined by numerical simulations utilizing the transfer matrix method (TMM). Key performance factors like sensitivity (S), full width at half maximum (FWHM), quality factor (QF), limit of detection (LoD), and detection accuracy (DA) have been evaluated for different cortisol concentrations. The results demonstrate a high sensitivity of 220 deg/RIU with QF of 60.06 RIU−1 and FWHM and DA of 3.73 deg and 0.273 deg−1. The TMM has been utilized to perform the numerical analysis, and a plane-polarised light source with a wavelength of about 633 nm (He–Ne laser) was employed.