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<p>A zirconium nitride (ZrN)-coated surface plasmon resonance (SPR) biosensor that targets particular biological components has been designed and simulated in this study. We illustrated the detection of glucose concentration in urine samples using numerical simulation based on the finite element method (FEM). The maximum angular sensitivity of the sensor was 315.74°/RIU at 0–15&#xa0;mg/dl (normal range) and 10&#xa0;g/dl of glucose concentration using refractive indices with a thickness of 48&#xa0;nm and 2&#xa0;nm of Ag and ZrN layer. Moreover, for the various concentrations like 0.625, 1.25, 2.5, 5, and 10&#xa0;g/dl, the sensitivity of 245.22°/RIU, 247.8°/RIU, 250.57°/RIU, 259.93°/RIU, and 283.42°/RIU are attained at minimum reflectivity (<i>R</i><sub>min</sub>) respectively. The corresponding penetration depth (PD) values are observed at 214.8, 216.4, 220.6, 222.3, 230.5, and 233.3&#xa0;nm, respectively. Therefore, the improved performance of the current SPR biosensor opens a new field in medical science and is suitable for urine glucose detection.</p>

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Detection of Urine Glucose Concentration Using Zirconium Nitride Surface Plasmon Resonance Sensor

  • 期刊论文

  • 发表日期：

    2025年3月6日

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  • Rajeev Kumar,
  • Yash Sharma,
  • Sudhakar T.,
  • Subhashree Ray,
  • Rekha M. M.,
  • Bhavik Jain,
  • Amrindra Pal

摘要

A zirconium nitride (ZrN)-coated surface plasmon resonance (SPR) biosensor that targets particular biological components has been designed and simulated in this study. We illustrated the detection of glucose concentration in urine samples using numerical simulation based on the finite element method (FEM). The maximum angular sensitivity of the sensor was 315.74°/RIU at 0–15 mg/dl (normal range) and 10 g/dl of glucose concentration using refractive indices with a thickness of 48 nm and 2 nm of Ag and ZrN layer. Moreover, for the various concentrations like 0.625, 1.25, 2.5, 5, and 10 g/dl, the sensitivity of 245.22°/RIU, 247.8°/RIU, 250.57°/RIU, 259.93°/RIU, and 283.42°/RIU are attained at minimum reflectivity (Rmin) respectively. The corresponding penetration depth (PD) values are observed at 214.8, 216.4, 220.6, 222.3, 230.5, and 233.3 nm, respectively. Therefore, the improved performance of the current SPR biosensor opens a new field in medical science and is suitable for urine glucose detection.