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<p>In this paper, we present the design of a high-performance surface plasmon resonance (SPR) sensor using perovskite material for the detection of malaria infection, specifically targeting the early stage (i.e., ring phase) of the plasmodium parasite lifecycle. The synergistic combination of perovskite material lead titanate (PbTiO<sub>3</sub>), known for its exceptional optical properties such as high refractive index (RI) and tunable bandgap, and silver metal, with its superior plasmonic characteristics, significantly enhances the sensitivity to a maximum of 410.8°/RIU for the proposed design. Further, the high Curie temperature of PbTiO<sub>3</sub>, offers thermal stability in high-temperature environments. The study exploits the Kretschmann configuration using transfer matrix method (TMM) based on angular interrogation to optimize the sensors’ performance. Further, the proposed design achieves the optimum quality factor of 105.18 RIU<sup>−1</sup> indicating its capability to detect subtle variations in the RI associated with the presence of malaria. The proposed SPR sensor offers a potential approach for early and precise malaria diagnosis, with a detection accuracy of 0.21&#xa0;deg<sup>-1</sup>, leveraging the enhanced plasmonic response to detect minimal RI changes associated with the presence of malaria. The proposed study highlights the potential of perovskite-based SPR sensors in biomedical applications, offering a reliable and efficient solution for malaria detection.</p>

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Sensitivity Enhancement of SPR Sensor with Si/Perovskite heterostructure for Early Detection of Malaria

  • 期刊论文

  • 发表日期：

    2025年2月12日

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  • Shivangani,
  • Anupam Sahu,
  • Dharmendra Kumar,
  • Sudhanshu Verma,
  • Sudakar Singh Chauhan,
  • Santosh Kumar

摘要

In this paper, we present the design of a high-performance surface plasmon resonance (SPR) sensor using perovskite material for the detection of malaria infection, specifically targeting the early stage (i.e., ring phase) of the plasmodium parasite lifecycle. The synergistic combination of perovskite material lead titanate (PbTiO3), known for its exceptional optical properties such as high refractive index (RI) and tunable bandgap, and silver metal, with its superior plasmonic characteristics, significantly enhances the sensitivity to a maximum of 410.8°/RIU for the proposed design. Further, the high Curie temperature of PbTiO3, offers thermal stability in high-temperature environments. The study exploits the Kretschmann configuration using transfer matrix method (TMM) based on angular interrogation to optimize the sensors’ performance. Further, the proposed design achieves the optimum quality factor of 105.18 RIU−1 indicating its capability to detect subtle variations in the RI associated with the presence of malaria. The proposed SPR sensor offers a potential approach for early and precise malaria diagnosis, with a detection accuracy of 0.21 deg-1, leveraging the enhanced plasmonic response to detect minimal RI changes associated with the presence of malaria. The proposed study highlights the potential of perovskite-based SPR sensors in biomedical applications, offering a reliable and efficient solution for malaria detection.