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<p>A sizable 430°/RIU (refractive index unit) sensitivity for the dengue detection is reported using the surface plasmon resonance (SPR) technique with the copper/compound semiconductor/BaTiO<sub>3</sub> configuration. The involvement of the copper makes the device significantly less expensive than the conventional gold (Au)/silver (Ag)-based SPR sensors and that can significantly lower the diagnostic cost. The study uses healthy and sickened plasma, platelets, and haemoglobin using blood as a biosample and shows the highest sensitivity for plasma, which notably contains the highest non-structural protein (NS1) in the early stage. The combined effect of compound semiconductor nitrides (aluminium nitrite (AlN), silicon nitrite (Si<sub>3</sub>N<sub>4</sub>), or gallium nitrite (GaN)) and BaTiO<sub>3</sub> helps to boost the sensor’s sensitivity and selectivity together. The angular sensitivity of 430°/RIU and quality factor (QF) of 136 RIU<sup>−1</sup> is achieved using Cu (58&#xa0;nm), AlN (14&#xa0;nm), and BaTiO<sub>3</sub> (1&#xa0;nm). The aforesaid advantages along with a visible operating wavelength of <i>λ</i> = 633&#xa0;nm make the proposed device a considerable design achievement for development of low-cost sensing equipment for efficient dengue detection.</p>

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Boosting the Sensitivity of Cu-based SPR Dengue Sensor Using Cu/Compound Semiconductor/BaTiO3 Configuration for Effective Early-Stage Dengue Detection

  • 期刊论文

  • 发表日期：

    2025年1月31日

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  • Sandipta Senapati,
  • Madhusudan Mishra

摘要

A sizable 430°/RIU (refractive index unit) sensitivity for the dengue detection is reported using the surface plasmon resonance (SPR) technique with the copper/compound semiconductor/BaTiO3 configuration. The involvement of the copper makes the device significantly less expensive than the conventional gold (Au)/silver (Ag)-based SPR sensors and that can significantly lower the diagnostic cost. The study uses healthy and sickened plasma, platelets, and haemoglobin using blood as a biosample and shows the highest sensitivity for plasma, which notably contains the highest non-structural protein (NS1) in the early stage. The combined effect of compound semiconductor nitrides (aluminium nitrite (AlN), silicon nitrite (Si3N4), or gallium nitrite (GaN)) and BaTiO3 helps to boost the sensor’s sensitivity and selectivity together. The angular sensitivity of 430°/RIU and quality factor (QF) of 136 RIU−1 is achieved using Cu (58 nm), AlN (14 nm), and BaTiO3 (1 nm). The aforesaid advantages along with a visible operating wavelength of λ = 633 nm make the proposed device a considerable design achievement for development of low-cost sensing equipment for efficient dengue detection.