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<p>This study presents a&#xa0; novel LSPR sensor for creatinine detection, incorporating functionalized carbon dots (CDsCOO) and silver nanotriangular (AgNT). CDsCOO was synthesized via a two-step hydrothermal process, with the characteristic carboxyl functional group at 1698 cm⁻<sup>1</sup> in FTIR spectra confirming successful synthesis. This functionalization enhanced creatinine binding through oxygen–hydrogen interactions, significantly improving sensor sensitivity. XPS analysis corroborated the presence of carbon and oxygen peaks at 284.35 eV and 530.95 eV, respectively, providing ample adsorption sites for creatinine. The AgNT/CDsCOO sensor exhibited exceptional sensitivity (3.696 nm/mg/dL) and a low detection limit of 0.06 mg/dL within the 0–0.8 mg/dL creatinine range. Selectivity studies demonstrated that CDsCOO is selective for creatinine. These findings highlight the potential of AgNT/CDsCOO as a promising material for creatinine sensing, with significant implications for clinical diagnostics and monitoring.</p>

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Sensitivity Improvement of Creatinine Detection Based on Functionalized Carbon Dots and Silver Nanotriangular Localized Surface Plasmon Resonance

  • 期刊论文

  • 发表日期：

    2025年1月11日

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  • Athiyah Sakinah Masran,
  • Nur Hidayah Azeman,
  • Wan Mohd Ebtisyam Mustaqim Mohd Daniyal,
  • Mohd Hafiz Abu Bakar,
  • Nur Afifah Ahmad Nazri,
  • Rozita Sulaiman,
  • Muhammad Rahimi Yusop,
  • Ahmad Rifqi Md Zain,
  • Ahmad Ashrif A Bakar

摘要

This study presents a  novel LSPR sensor for creatinine detection, incorporating functionalized carbon dots (CDsCOO) and silver nanotriangular (AgNT). CDsCOO was synthesized via a two-step hydrothermal process, with the characteristic carboxyl functional group at 1698 cm⁻1 in FTIR spectra confirming successful synthesis. This functionalization enhanced creatinine binding through oxygen–hydrogen interactions, significantly improving sensor sensitivity. XPS analysis corroborated the presence of carbon and oxygen peaks at 284.35 eV and 530.95 eV, respectively, providing ample adsorption sites for creatinine. The AgNT/CDsCOO sensor exhibited exceptional sensitivity (3.696 nm/mg/dL) and a low detection limit of 0.06 mg/dL within the 0–0.8 mg/dL creatinine range. Selectivity studies demonstrated that CDsCOO is selective for creatinine. These findings highlight the potential of AgNT/CDsCOO as a promising material for creatinine sensing, with significant implications for clinical diagnostics and monitoring.