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<p>Photonic crystal fiber (PCF)–based surface plasmon resonance (SPR) biosensors have emerged as highly sensitive tools for detecting biomolecules, offering tremendous potential in cancer cell detection. This research proposes a novel high-sensitivity PCF SPR biosensor, designed with a gold-coated circular-shaped structure, for the precise detection of various cancer cells. Gold is selected as the foundational material due to its superior plasmonic activity, ensuring optimal resonance compared to other plasmonic materials. The biosensor’s performance is analyzed using refractive indices (RIs) ranging from 1.380 to 1.401, specifically 1.380, 1.390, 1.392, 1.395, 1.399, and 1.401, across a wavelength range of 0.96 to 1.06&#xa0;nm. The finite element method (FEM) is used to evaluate the sensor’s characteristics. The highest wavelength sensitivity (WS) of 13257.20&#xa0;nm/RIU is obtained at a refractive index of 1.380, indicating the sensor’s exceptional ability to detect minute changes in cancer cell concentrations. The biosensor also exhibits a high figure of merit (FOM) of 36.52 RIU⁻<sup>1</sup> and a limit of detection (LOD) of 397&#xa0;nm. Furthermore, the proposed structure exhibits maximum values of birefringence, coupling length, power spectrum, and transmittance, which are 8.30 × 10<sup>−4</sup>, 7.88 × 10<sup>2</sup>&#xa0;µm, 1&#xa0;dB/m, and − 42.574&#xa0;dB, respectively. These results highlight the biosensor’s significant potential in cancer diagnostics by offering high precision and sensitivity, positioning it as a valuable tool for early cancer detection and monitoring.</p>

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Design and Investigation of High-Sensitivity PCF SPR Biosensor for Various Cancer Cells Detection Using a Gold-Coated Circular-Shaped Structure

  • 期刊论文

  • 发表日期：

    2024年12月31日

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  • Sonia Akter,
  • Hasan Abdullah

摘要

Photonic crystal fiber (PCF)–based surface plasmon resonance (SPR) biosensors have emerged as highly sensitive tools for detecting biomolecules, offering tremendous potential in cancer cell detection. This research proposes a novel high-sensitivity PCF SPR biosensor, designed with a gold-coated circular-shaped structure, for the precise detection of various cancer cells. Gold is selected as the foundational material due to its superior plasmonic activity, ensuring optimal resonance compared to other plasmonic materials. The biosensor’s performance is analyzed using refractive indices (RIs) ranging from 1.380 to 1.401, specifically 1.380, 1.390, 1.392, 1.395, 1.399, and 1.401, across a wavelength range of 0.96 to 1.06 nm. The finite element method (FEM) is used to evaluate the sensor’s characteristics. The highest wavelength sensitivity (WS) of 13257.20 nm/RIU is obtained at a refractive index of 1.380, indicating the sensor’s exceptional ability to detect minute changes in cancer cell concentrations. The biosensor also exhibits a high figure of merit (FOM) of 36.52 RIU⁻1 and a limit of detection (LOD) of 397 nm. Furthermore, the proposed structure exhibits maximum values of birefringence, coupling length, power spectrum, and transmittance, which are 8.30 × 10−4, 7.88 × 102 µm, 1 dB/m, and − 42.574 dB, respectively. These results highlight the biosensor’s significant potential in cancer diagnostics by offering high precision and sensitivity, positioning it as a valuable tool for early cancer detection and monitoring.