Characterization and Antibacterial Properties of CoCrCuFeNi High-Entropy Alloy Nanoparticles Synthesized by Lactobacillus acidophilus
摘要
Lactobacillus acidophilus (LB) can produce high-purity nanoparticles; it is a top-down biological method based on the principle of dividing metal ion bulk precursors into metal atoms; this biosynthesis method was used in this work to synthesize CoCrCuFeNi high-entropy alloy. The characteristics of the synthesized nanoparticles were examined using XRD, SEM, and FTIR analysis. Subsequently, their antibacterial and antibiofilm activities were tested against a Gram-positive bacteria Staphylococcus aureus (S. aureus) and a Gram-negative bacteria Escherichia coli (E. coli) that were isolated from the urinary tract infection. The results indicated that CoCrCuFeNi HEA NPs produced via the LB, along with CoCrCuFeNi HEA NPs + LB supernatant, displayed antibacterial inhibition zones measuring 35 mm against E. coli and 25 mm against S. aureus. On the other hand, the antibiofilm effectiveness of the CoCrCuFeNi HEA NPs + LB on a catheter was determined to surpass 45% against E. coli.