<p>Clip chemistry (CC) is an innovative interdisciplinary approach for biomanufacture and chemical engineering, significantly contributing to the synthesis of functional materials and chemicals. This method precisely regulates the evolution of the chemical bonds at the molecular level, achieving efficient conversion from basic raw materials to target products. The progress made in clip chemistry has significantly accelerated the sustainable development of chemical synthesis. Upon transitioning from the solid to the liquid state, gallium-based liquid metals (GBLMs) exhibit a highly reactive surface state characterized by enhanced surface reactivity. Owing to these properties, GBLMs can rapidly, directionally, and spontaneously facilitate the site-specific cleavage of the oxygen-containing covalent bonds, such as those in the methanol (CH₃OH) molecules. The cleavage of the C–O, C–H, and H–O bonds of CH₃OH molecules results in the formation of reactive groups. Gallium ions (Ga³⁺) combine with oxide ions (O²⁻) and hydroxyl groups (–OH) to form gallium oxide hydroxide (GaO(OH)) semiconducting material, while the remaining active species include carbon materials, hydrocarbons, and metal salts. We thus demonstrate that GBLMs have emerged as a transformative medium for the directional tailoring and synthesis of oxygen-containing molecules and other related materials. The advancement reported here has significantly enhanced our understanding of the interaction between GBLMs and molecules, molecular CC, and oxygen-containing molecular systems. Moreover, it has a great potential to propel the practical application of techniques involving molecular scission and recombination. GBLMs thus have significant potential across molecular engineering, energy-environment systems, and biomedical research domains.</p>