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<p>Tumor cell membrane (TCM) camouflaged nanoparticles (NPs) are potential biomimetic drug-delivery vehicles that can be leveraged for cancer therapy. We developed a practical, minimalist TCM-camouflaged nanosystem for efficient cancer-active targeting chemo-immunotherapy. The tumor immunogenic cell death (ICD) initiator <i>cis</i>-aconityl-doxorubicin (CAD) and unmethylated cytosine-phosphate-guanine (CpG) immunoadjuvant were co-hitchhiked with polyethylenimine (PEI) to generate PEI/CpG/CAD (PGD) NPs, which were further cloaked with TCM to facilitate prolonged systemic circulation, homologous tumor targeting, and efficacious internalization in membrane-sourcing tumor cells through self-recognition and adhesion. After the PGD@TCM nanosystem was internalized by tumor cells, CAD was cleaved in the acidic endosomes and converted into doxorubicin to elicit ICD for the activation of robust tumor-specific immune responses. This study presents a promising nanoplatform for cancer chemo-immunotherapy, wherein the drug, adjuvant, and TCM could be substituted and purposefully redeployed through the flexible collocation of each component. Moreover, this nanosystem could be extended for the precise personalized cancer chemo-immunotherapy of various tumor types.</p>

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A versatile tumor cell membrane-camouflaged biomimetic nanosystem for efficient cancer active targeting chemo-immunotherapy

  • 期刊论文

  • 发表日期：

    2026年5月22日

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  • Jun Zeng,
  • Yunfei Han,
  • Xinyu Li,
  • Hui Liang,
  • Wenqiang Chen,
  • Xiuwen Guan,
  • Weifen Zhang

摘要

Tumor cell membrane (TCM) camouflaged nanoparticles (NPs) are potential biomimetic drug-delivery vehicles that can be leveraged for cancer therapy. We developed a practical, minimalist TCM-camouflaged nanosystem for efficient cancer-active targeting chemo-immunotherapy. The tumor immunogenic cell death (ICD) initiator cis-aconityl-doxorubicin (CAD) and unmethylated cytosine-phosphate-guanine (CpG) immunoadjuvant were co-hitchhiked with polyethylenimine (PEI) to generate PEI/CpG/CAD (PGD) NPs, which were further cloaked with TCM to facilitate prolonged systemic circulation, homologous tumor targeting, and efficacious internalization in membrane-sourcing tumor cells through self-recognition and adhesion. After the PGD@TCM nanosystem was internalized by tumor cells, CAD was cleaved in the acidic endosomes and converted into doxorubicin to elicit ICD for the activation of robust tumor-specific immune responses. This study presents a promising nanoplatform for cancer chemo-immunotherapy, wherein the drug, adjuvant, and TCM could be substituted and purposefully redeployed through the flexible collocation of each component. Moreover, this nanosystem could be extended for the precise personalized cancer chemo-immunotherapy of various tumor types.