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<p>Bacterial infections pose persistent threats to global public health, while the antimicrobial resistance caused by the overuse of antibiotics further exacerbates this problem. The development of novel disinfectants that are efficient, durable, broad-spectrum, and deploy non-antibiotic mechanisms is therefore highly desired. Multifunctional nanocomposites with multi-effect antibacterial properties can meet the above demands. Herein, we developed a core-shell nanocomposite of Au-Ag nano-urchins coated with room-temperature synthesized covalent organic frameworks for efficient morin loading and multi-scenario antibacterial applications. This material achieves exceptional bactericidal efficacy at ultralow doses by combining photothermal therapy, tip-mediated physical puncture, and the action of released antibacterial components. It achieves over 99.99% in-activation of both <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> at a low concentration of 8 µg mL<sup>−1</sup> under weak xenon lamp illumination of 0.3 W cm<sup>−2</sup>. The nanocomposites can be readily spray-coated onto various surfaces, forming a durable and stable antibacterial layer. Furthermore, in the <i>in vivo</i> infected wound healing model, the nanocomposite demonstrated excellent antibacterial efficacy and promoted nearly complete wound closure within 7 days. By integrating physical puncture, photothermal effect, and controlled drug/ion release, this nanocomposite offers an effective strategy for daily antibacterial applications.</p>

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Sprayable RT-COF-coated Au-Ag nano-urchins for controllable drug delivery and chemo-photothermal combined antibacterial applications

  • 期刊论文

  • 发表日期：

    2026年4月15日

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  • Jiaxin Niu,
  • Hangyang Ling,
  • Xu Sun,
  • Gongxian Sun,
  • Shengyan Wang,
  • Feiyan Li,
  • Na Zhang,
  • Tianshuang Chen,
  • Xiaolu Zhuo,
  • Jinjin Zhu,
  • Han Zhang,
  • Xiangdong Kong

摘要

Bacterial infections pose persistent threats to global public health, while the antimicrobial resistance caused by the overuse of antibiotics further exacerbates this problem. The development of novel disinfectants that are efficient, durable, broad-spectrum, and deploy non-antibiotic mechanisms is therefore highly desired. Multifunctional nanocomposites with multi-effect antibacterial properties can meet the above demands. Herein, we developed a core-shell nanocomposite of Au-Ag nano-urchins coated with room-temperature synthesized covalent organic frameworks for efficient morin loading and multi-scenario antibacterial applications. This material achieves exceptional bactericidal efficacy at ultralow doses by combining photothermal therapy, tip-mediated physical puncture, and the action of released antibacterial components. It achieves over 99.99% in-activation of both Escherichia coli and Staphylococcus aureus at a low concentration of 8 µg mL−1 under weak xenon lamp illumination of 0.3 W cm−2. The nanocomposites can be readily spray-coated onto various surfaces, forming a durable and stable antibacterial layer. Furthermore, in the in vivo infected wound healing model, the nanocomposite demonstrated excellent antibacterial efficacy and promoted nearly complete wound closure within 7 days. By integrating physical puncture, photothermal effect, and controlled drug/ion release, this nanocomposite offers an effective strategy for daily antibacterial applications.