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<p>Although lettuce (<i>Lactuca sativa</i> L.) is known for its high flavonoid content, the regulatory mechanisms of flavonoid biosynthesis are yet to be fully investigated. A metabolic network profile was constructed based on metabolomic and transcriptomic datasets derived from five lettuce growth stages. From this analysis, we identified 201 metabolites and 15,775 co-expressed genes, which were subsequently organized into six distinct expression modules. A novel flavonoid biosynthesis regulatory network emerged, comprising the transcription factors LsBBX20, LsMYB114, and LsMYB114-like. Each of these three factors was found to individually regulate the expression of flavonoid biosynthesis genes. LsBBX20 further regulates the expression of <i>LsMYB114</i> and <i>LsMYB114-like</i> in a light-dependent manner. The results of this study include not only a novel regulatory network of flavonoid biosynthesis but also a valuable dataset for the systematic investigation of metabolic regulation in lettuce.</p>

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Multi-omics study reveals a light-dependent regulatory network of flavonoid biosynthesis in lettuce (Lactuca sativa L.)

  • 期刊论文

  • 发表日期：

    2025年5月30日

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  • Yuting Xiang,
  • Shuxin Zheng,
  • Hsihua Wang,
  • Bang Chen,
  • Rao Fu,
  • Tao Huang,
  • Li Zhang,
  • Bo Song,
  • Yuejian Li,
  • Qichang Yang,
  • Xiao Yang,
  • Yang Zhang

摘要

Although lettuce (Lactuca sativa L.) is known for its high flavonoid content, the regulatory mechanisms of flavonoid biosynthesis are yet to be fully investigated. A metabolic network profile was constructed based on metabolomic and transcriptomic datasets derived from five lettuce growth stages. From this analysis, we identified 201 metabolites and 15,775 co-expressed genes, which were subsequently organized into six distinct expression modules. A novel flavonoid biosynthesis regulatory network emerged, comprising the transcription factors LsBBX20, LsMYB114, and LsMYB114-like. Each of these three factors was found to individually regulate the expression of flavonoid biosynthesis genes. LsBBX20 further regulates the expression of LsMYB114 and LsMYB114-like in a light-dependent manner. The results of this study include not only a novel regulatory network of flavonoid biosynthesis but also a valuable dataset for the systematic investigation of metabolic regulation in lettuce.