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<p>Zika virus (ZIKV) has emerged as a global health priority due to its association with severe congenital abnormalities, including microcephaly and neonatal mortality in infants born to infected mothers. In adults, ZIKV infection is epidemiologically linked to Guillain-Barré Syndrome (GBS). These clinical manifestations prompted the World Health Organization (WHO) to declare ZIKV a Public Health Emergency of International Concern (PHEIC). The antibody-dependent enhancement (ADE) phenomenon further complicates vaccine development and therapeutic strategies. While substantial progress has been made in elucidating ZIKV biology through multidisciplinary approaches, no vaccines or therapies have been clinically approved. This review examines ZIKV-associated risks by analyzing transmission dynamics, viral architecture, and cellular entry mechanisms, and proposes evidence-based prevention and management strategies.</p>

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Bioprofiling and vaccine development for Zika virus

  • 期刊论文

  • 发表日期：

    2025年6月3日

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  • Huiping Shi,
  • Shengyong Feng,
  • Abid Naeem,
  • Baoying Huang,
  • Wenjie Tan,
  • Lulu Zheng,
  • Xing-Jie Liang,
  • Minghui Yang,
  • Yuanyu Huang

摘要

Zika virus (ZIKV) has emerged as a global health priority due to its association with severe congenital abnormalities, including microcephaly and neonatal mortality in infants born to infected mothers. In adults, ZIKV infection is epidemiologically linked to Guillain-Barré Syndrome (GBS). These clinical manifestations prompted the World Health Organization (WHO) to declare ZIKV a Public Health Emergency of International Concern (PHEIC). The antibody-dependent enhancement (ADE) phenomenon further complicates vaccine development and therapeutic strategies. While substantial progress has been made in elucidating ZIKV biology through multidisciplinary approaches, no vaccines or therapies have been clinically approved. This review examines ZIKV-associated risks by analyzing transmission dynamics, viral architecture, and cellular entry mechanisms, and proposes evidence-based prevention and management strategies.