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<p>Perioperative neurocognitive disorder (PND) is a significant neurological complication in aging perioperative patients that impacts post-operative cognition. PND is currently diagnosed through cognitive function testing, which is limited by its subjectivity and time requirements. Thus, the identification of biomarkers to assess PND onset is a priority to identify at-risk individuals and enable interventions and treatments to patient outcomes. This article synthesizes expert perspectives on brain aging and PND, presents the latest clinical evidence on PND biomarkers (imaging, electroencephalography, and molecular biomarkers), and delves into the relationship between PND and other age-related cognitive disorders. Thorough review of PND research identified several biomarkers with high sensitivity and specificity, offering a solid scientific foundation to predict and diagnose PND. These biomarkers not only enhance diagnostic accuracy for clinicians but also provide opportunities for earlier intervention and more effective treatment, potentially enhancing patient outcomes and quality of life.</p>

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Clinical biomarkers of perioperative neurocognitive disorder: initiation and recommendation

  • 期刊论文

  • 发表日期：

    2025年1月22日

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  • Jianhui Liu,
  • Cheng Li,
  • Junyan Yao,
  • Lei Zhang,
  • Xuan Zhao,
  • Xin Lv,
  • Zhiqiang Liu,
  • Changhong Miao,
  • Yingwei Wang,
  • Hong Jiang,
  • Weifeng Yu,
  • Tianlong Wang,
  • Dongxin Wang,
  • E. Wang,
  • Xiaoping Gu,
  • Hailong Dong,
  • Junli Cao,
  • Yuan Shen,
  • Weihong Song,
  • Shengdi Chen,
  • Yanjiang Wang,
  • Guanghui Liu,
  • Zhongcong Xie,
  • Lize Xiong,
  • Jialin C. Zheng

摘要

Perioperative neurocognitive disorder (PND) is a significant neurological complication in aging perioperative patients that impacts post-operative cognition. PND is currently diagnosed through cognitive function testing, which is limited by its subjectivity and time requirements. Thus, the identification of biomarkers to assess PND onset is a priority to identify at-risk individuals and enable interventions and treatments to patient outcomes. This article synthesizes expert perspectives on brain aging and PND, presents the latest clinical evidence on PND biomarkers (imaging, electroencephalography, and molecular biomarkers), and delves into the relationship between PND and other age-related cognitive disorders. Thorough review of PND research identified several biomarkers with high sensitivity and specificity, offering a solid scientific foundation to predict and diagnose PND. These biomarkers not only enhance diagnostic accuracy for clinicians but also provide opportunities for earlier intervention and more effective treatment, potentially enhancing patient outcomes and quality of life.