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<p>The mutually exacerbating vicious cycle of infection and hemorrhage represents a critical clinical challenge impeding wound healing. To address this issue, this study developed an intelligent quaternized chitosan-based dressing (PQAB) loaded with Au nanocage-AIE photosensitizer composite nanoparticles, aiming to achieve discriminative imaging and synergistic therapy for infected hemorrhagic wounds. At the diagnostic level, leveraging the surface modification of Au nanocages (AuNCs) with 4-mercaptophenylboronic acid (4-MPBA) and 4-mercaptobenzonitrile (4-MBN), the dressing enables simultaneous specific fluorescence labeling of Gram-positive bacteria and broad-spectrum surface-enhanced Raman scattering (SERS) imaging of pathogens, allowing precise identification of infection types through a discriminative imaging strategy. Therapeutically, light irradiation triggers the photothermal effect of the AuNCs, controllably releasing the encapsulated AIE photosensitizer (<b>BD-1</b>), thereby inducing a synergistic bactericidal effect via photothermal therapy (PTT) and photodynamic therapy (PDT). Concurrently, the quaternized chitosan (QCS) in the dressing substrate independently functions for rapid hemostasis. The integration of these three core functions effectively accelerates the healing of infected hemorrhagic wounds and further provides a novel, translationally promising solution for addressing the repair of such wounds.</p>

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Discriminative imaging strategy-guided smart dressings: synergizing hemostasis, pathogen typing and antimicrobial phototherapy

  • 期刊论文

  • 发表日期：

    2026年6月15日

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  • Feng-Rui Xu,
  • Guohua Li,
  • Hongxiang Liu,
  • Rong Yang,
  • Yifan Niu,
  • Bingbing Fan,
  • Peiyan Gong,
  • Guojun Yu,
  • Ni-Ni Zhou,
  • Hai-Tao Zhu,
  • Ben Zhong Tang,
  • Hai-Tao Feng

摘要

The mutually exacerbating vicious cycle of infection and hemorrhage represents a critical clinical challenge impeding wound healing. To address this issue, this study developed an intelligent quaternized chitosan-based dressing (PQAB) loaded with Au nanocage-AIE photosensitizer composite nanoparticles, aiming to achieve discriminative imaging and synergistic therapy for infected hemorrhagic wounds. At the diagnostic level, leveraging the surface modification of Au nanocages (AuNCs) with 4-mercaptophenylboronic acid (4-MPBA) and 4-mercaptobenzonitrile (4-MBN), the dressing enables simultaneous specific fluorescence labeling of Gram-positive bacteria and broad-spectrum surface-enhanced Raman scattering (SERS) imaging of pathogens, allowing precise identification of infection types through a discriminative imaging strategy. Therapeutically, light irradiation triggers the photothermal effect of the AuNCs, controllably releasing the encapsulated AIE photosensitizer (BD-1), thereby inducing a synergistic bactericidal effect via photothermal therapy (PTT) and photodynamic therapy (PDT). Concurrently, the quaternized chitosan (QCS) in the dressing substrate independently functions for rapid hemostasis. The integration of these three core functions effectively accelerates the healing of infected hemorrhagic wounds and further provides a novel, translationally promising solution for addressing the repair of such wounds.