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<p>Aging is a highly individualized process that is influenced by genetics, environment, lifestyle, and health status. Lung aging serves as a critical health monitoring indicator that aids individuals and healthcare providers in long-term health management. To date, there have been no methods for studying lung aging <i>in vivo</i>. In this study, we developed the photoacoustic probe <b>SHLGAL</b> by conjugating a lung-targeting dye with β-galactoside, a substrate for the cellular senescence biomarker β-galactosidase, enabling the first-ever detection of lung aging <i>in vivo</i>. Initially, both <i>in vivo</i> and <i>in vitro</i> experiments demonstrated that the probe <b>SHLGAL</b> effectively responds to β-galactosidase, highlighting its potential for studying aging. Then, we coined the term “ChemBio Imaging Approach (CBIA)” to describe the method that combines the probe <b>SHLGAL</b> with photoacoustic imaging technology for the detection of lung aging. This approach firstly enables noninvasive, <i>in vivo</i> detection of lung aging with straightforward procedures. Finally, using CBIA, we successfully detected the smoking-induced lung aging <i>in vivo</i> and, for the first time, identified the potential of dasatinib and quercetin in preventing smoking-induced lung lesions, presenting a promising strategy with significant therapeutic implications.</p>

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A photoacoustic probe for in vivo detection of lung aging: toward the prevention of smoking-induced lung lesions

  • 期刊论文

  • 发表日期：

    2026年5月26日

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  • Zihong Li,
  • Hanwen Chi,
  • Huayong Zhu,
  • Ping Huang,
  • Ling Huang,
  • Weiying Lin

摘要

Aging is a highly individualized process that is influenced by genetics, environment, lifestyle, and health status. Lung aging serves as a critical health monitoring indicator that aids individuals and healthcare providers in long-term health management. To date, there have been no methods for studying lung aging in vivo. In this study, we developed the photoacoustic probe SHLGAL by conjugating a lung-targeting dye with β-galactoside, a substrate for the cellular senescence biomarker β-galactosidase, enabling the first-ever detection of lung aging in vivo. Initially, both in vivo and in vitro experiments demonstrated that the probe SHLGAL effectively responds to β-galactosidase, highlighting its potential for studying aging. Then, we coined the term “ChemBio Imaging Approach (CBIA)” to describe the method that combines the probe SHLGAL with photoacoustic imaging technology for the detection of lung aging. This approach firstly enables noninvasive, in vivo detection of lung aging with straightforward procedures. Finally, using CBIA, we successfully detected the smoking-induced lung aging in vivo and, for the first time, identified the potential of dasatinib and quercetin in preventing smoking-induced lung lesions, presenting a promising strategy with significant therapeutic implications.