Scholarlink

<p>Photoactivated metallic drugs provide a straightforward strategy for precise cancer phototherapy. However, the small molar extinction coefficient in the near infrared (NIR) region limits the clinical application. In this study, we report the self-assembling dinuclear tris-bidentate Ru(II) complex with NIR light absorption and emission properties. <b>Ru2C</b> forms a nanowire via <i>π</i>-<i>π</i> interaction with high photostability and low dark toxicity. Upon 700 nm light excitation, <b>Ru2C</b> exhibits synergistic type I/II photosensitization and in-cell photocatalysis activity, with high phototherapeutic effect toward cancer cell monolayers, spheroids <i>in vitro</i> and orthotopic 4T1 breast tumor <i>in vivo</i>. Both non-targeted and pseudo-targeted metabolomics analysis reveal that <b>Ru2C</b> disrupts the cellular metabolism including energy production and biosynthesis. This work provides a new avenue to construct self-assembling and NIR light-activated Ru(II) complexes for cancer phototherapy.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Near infrared light activated Ru(II) complexes disrupt energy metabolism of cancer cells

  • 期刊论文

  • 发表日期：

    2026年5月7日

查看全文
  • Anyi Dao,
  • Haorui Wu,
  • Yuanlu Sun,
  • Yafei You,
  • Li Wei,
  • Haobing Wang,
  • Juyang Huang,
  • Haotu Zhu,
  • Xin Zhang,
  • Pingyu Zhang,
  • Huaiyi Huang

摘要

Photoactivated metallic drugs provide a straightforward strategy for precise cancer phototherapy. However, the small molar extinction coefficient in the near infrared (NIR) region limits the clinical application. In this study, we report the self-assembling dinuclear tris-bidentate Ru(II) complex with NIR light absorption and emission properties. Ru2C forms a nanowire via π-π interaction with high photostability and low dark toxicity. Upon 700 nm light excitation, Ru2C exhibits synergistic type I/II photosensitization and in-cell photocatalysis activity, with high phototherapeutic effect toward cancer cell monolayers, spheroids in vitro and orthotopic 4T1 breast tumor in vivo. Both non-targeted and pseudo-targeted metabolomics analysis reveal that Ru2C disrupts the cellular metabolism including energy production and biosynthesis. This work provides a new avenue to construct self-assembling and NIR light-activated Ru(II) complexes for cancer phototherapy.