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<p>In biology, metal ions are fundamental to protein structure and function, directing folding through coordination chemistry and serving as active centers for catalysis, transport, and signaling. Synthetic poly(amino acids) (PAAs) are biomimetic polymers that combine exceptional tailorability and biocompatibility with well-defined secondary structures. The integration of metal ions with PAAs creates metallo-poly(amino acids) (MPAAs), where coordination to main-chain or side-chain ligands provides a powerful strategy to dictate conformational landscape and drive hierarchical self-assembly. This control, in turn, imbues the resulting supramolecular architectures with unique biological functions. This perspective systematically outlines the fundamental principles and strategies for manipulating PAA secondary structures and self-assembly via metal coordination. We then detail recent advances in MPAAs for applications in bioimaging, catalytic therapy, drug delivery, and biomimetic mineralization. Finally, we provide a critical perspective on the challenges and future research directions in this burgeoning field, highlighting the path toward rationally designed MPAAs for sophisticated biomedical and materials applications.</p>

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Metallo-poly(amino acids): coordination-driven hierarchical self-assembly, functionalization, and biomedical applications

  • 期刊论文

  • 发表日期：

    2026年5月14日

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  • Zuojie Wang,
  • Linxi Xu,
  • Xiu Zhang,
  • Yan Luo,
  • Qianru Xu,
  • Fan Fan,
  • Yi Zheng,
  • Chuan Peng,
  • Yeqiang Zhou,
  • Huixu Xie,
  • Mingming Ding

摘要

In biology, metal ions are fundamental to protein structure and function, directing folding through coordination chemistry and serving as active centers for catalysis, transport, and signaling. Synthetic poly(amino acids) (PAAs) are biomimetic polymers that combine exceptional tailorability and biocompatibility with well-defined secondary structures. The integration of metal ions with PAAs creates metallo-poly(amino acids) (MPAAs), where coordination to main-chain or side-chain ligands provides a powerful strategy to dictate conformational landscape and drive hierarchical self-assembly. This control, in turn, imbues the resulting supramolecular architectures with unique biological functions. This perspective systematically outlines the fundamental principles and strategies for manipulating PAA secondary structures and self-assembly via metal coordination. We then detail recent advances in MPAAs for applications in bioimaging, catalytic therapy, drug delivery, and biomimetic mineralization. Finally, we provide a critical perspective on the challenges and future research directions in this burgeoning field, highlighting the path toward rationally designed MPAAs for sophisticated biomedical and materials applications.