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<p>High-quality recording of neural signals relies on interfacial compatibility between implanted electrodes and brain tissue. Flexible hydrogel electrodes achieve a snugger interfacial contact with nerve tissue than conventional metal electrodes, but their lower conductivity leads to a decrease in the accuracy of neural signal monitoring. Herein, highly conductive flexible hydrogel bioelectrodes with dual-mode electron-ionic conduction (EIC) were prepared by combining bio-based ionic liquids (BILs) with conductive polymers to construct stable and biocompatible electrode-nerve interfaces. The BILs enhanced the ordered stacking of the conductive polymers through counterionic interactions, thus guaranteeing efficient electron-ionic dual carrier transport and reducing the interfacial impedance between electrodes and brain tissue. Implantation of EIC hydrogel bioelectrodes into the primary motor cortex of freely moving mice enabled accurate recording of neural signals with higher signal-to-noise ratios than those of metal electrodes, which is of great significance for the development of neural decoding and bioelectronics.</p>

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Dual-mode electron-ionic conductive hydrogel bioelectrodes for recording neural signals

  • 期刊论文

  • 发表日期：

    2026年4月7日

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  • Lingling Li,
  • Xiaoxia Li,
  • Yichen Ding,
  • Ziying Pan,
  • Shengwei Jia,
  • Xiaoliang Wang,
  • Qun-Dong Shen

摘要

High-quality recording of neural signals relies on interfacial compatibility between implanted electrodes and brain tissue. Flexible hydrogel electrodes achieve a snugger interfacial contact with nerve tissue than conventional metal electrodes, but their lower conductivity leads to a decrease in the accuracy of neural signal monitoring. Herein, highly conductive flexible hydrogel bioelectrodes with dual-mode electron-ionic conduction (EIC) were prepared by combining bio-based ionic liquids (BILs) with conductive polymers to construct stable and biocompatible electrode-nerve interfaces. The BILs enhanced the ordered stacking of the conductive polymers through counterionic interactions, thus guaranteeing efficient electron-ionic dual carrier transport and reducing the interfacial impedance between electrodes and brain tissue. Implantation of EIC hydrogel bioelectrodes into the primary motor cortex of freely moving mice enabled accurate recording of neural signals with higher signal-to-noise ratios than those of metal electrodes, which is of great significance for the development of neural decoding and bioelectronics.