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<p>Bioactive pressure-sensitive adhesives (PSAs) capable of integrating appropriate adhesion, mechanical robustness, and therapeutic functionality are highly desirable for advanced wound management. Here, we report a nanoconfined polymerization strategy to construct a multifunctional PSA elastomer by confining thioctic acid (TA) within halloysite nanotubes (HNTs). The confined ring-opening polymerization of TA within the positively charged, hydroxyl-rich lumens of HNTs enhances monomer conversion and forms a topologically interlocked polymer network, significantly stabilizing the metastable poly(thioctic acid) (PTA). This architecture imparts the elastomer with outstanding mechanical performance (1290% stretchability, 600× weight-bearing, 94.1% self-healing efficiency) and appropriate tissue adhesion (5.5 N cm<sup>−1</sup>). <i>In vivo</i> studies demonstrate that the obtained PTA-HNT PSA elastomer effectively seals wounds, reduces blood loss, and shortens bleeding time in both femoral artery and tail amputation models. Moreover, the incorporation of HNTs significantly mitigates PTA depolymerization, improving the biocompatibility of the composite while providing sustained antioxidant and antibacterial effects that promote the healing of infected wounds. This recyclable, solvent-free PSA design introduces a physical stabilization paradigm, offering a promising strategy for the development of next-generation bioactive PSAs for advanced wound care and biomedical applications.</p>

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Nanoconfined polymerization of thioctic acid in halloysite nanotubes: bioactive pressure-sensitive adhesive elastomer for rapid wound closure

  • 期刊论文

  • 发表日期：

    2026年1月15日

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  • Jiaxin Zhang,
  • Songming Wu,
  • Zhen Huang,
  • Xiaoyan Zhu,
  • Sen Zhou,
  • Heng Deng,
  • Huageng Liang,
  • Yuting Gao

摘要

Bioactive pressure-sensitive adhesives (PSAs) capable of integrating appropriate adhesion, mechanical robustness, and therapeutic functionality are highly desirable for advanced wound management. Here, we report a nanoconfined polymerization strategy to construct a multifunctional PSA elastomer by confining thioctic acid (TA) within halloysite nanotubes (HNTs). The confined ring-opening polymerization of TA within the positively charged, hydroxyl-rich lumens of HNTs enhances monomer conversion and forms a topologically interlocked polymer network, significantly stabilizing the metastable poly(thioctic acid) (PTA). This architecture imparts the elastomer with outstanding mechanical performance (1290% stretchability, 600× weight-bearing, 94.1% self-healing efficiency) and appropriate tissue adhesion (5.5 N cm−1). In vivo studies demonstrate that the obtained PTA-HNT PSA elastomer effectively seals wounds, reduces blood loss, and shortens bleeding time in both femoral artery and tail amputation models. Moreover, the incorporation of HNTs significantly mitigates PTA depolymerization, improving the biocompatibility of the composite while providing sustained antioxidant and antibacterial effects that promote the healing of infected wounds. This recyclable, solvent-free PSA design introduces a physical stabilization paradigm, offering a promising strategy for the development of next-generation bioactive PSAs for advanced wound care and biomedical applications.