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<p>Accurate and sensitive determination of uric acid (UA) is critical, as abnormal UA concentrations are associated with various pathologies. Electrochemical sensing is an effective method for the detection of UA concentrations. The electrochemical behavior of UA sensors is fundamentally governed by the electronic configurations of catalytically active sites, where enhanced site activity significantly improves overall performance. In this work, biocompatible g-C<sub>3</sub>N<sub>4</sub> is selectively doped with cobalt to generate UA-specific surface centers. These are synergistically integrated with highly conductive Ti<sub>3</sub>CN to optimize charge transport efficiency. The oxygen-terminated surface of Ti<sub>3</sub>CN forms strong chemical bonds with the Co-doped sites, enabling precise modulation of their electronic structure. DFT calculations reveal substantial electron transfer from cobalt atoms to surface oxygen groups, which shifts the Co d-band center, reduces the desorption barrier for UA oxidation intermediates, and accelerates the catalytic process. The resulting Co-CN/Ti<sub>3</sub>CN-modified GCE demonstrates a broad linear detection range and ultralow detection limit. This study establishes an atomic-scale design strategy for electrochemical sensors capable of trace-level UA detection, offering a promising platform for clinical diagnostics and biomedical monitoring.</p>

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Boosting ultra-sensitive electrochemical sensing of uric acid through spatial extra oxygen coordination of Co-CN/Ti3CN

  • 期刊论文

  • 发表日期：

    2025年12月3日

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  • Jiahe Peng,
  • Dongxiao Wen,
  • Yilin Li,
  • Xiaoxian Hu,
  • Qian Zhou,
  • Shuangshuang Huang,
  • Yuandong Zhao,
  • Weiping Gong,
  • Jizhou Jiang

摘要

Accurate and sensitive determination of uric acid (UA) is critical, as abnormal UA concentrations are associated with various pathologies. Electrochemical sensing is an effective method for the detection of UA concentrations. The electrochemical behavior of UA sensors is fundamentally governed by the electronic configurations of catalytically active sites, where enhanced site activity significantly improves overall performance. In this work, biocompatible g-C3N4 is selectively doped with cobalt to generate UA-specific surface centers. These are synergistically integrated with highly conductive Ti3CN to optimize charge transport efficiency. The oxygen-terminated surface of Ti3CN forms strong chemical bonds with the Co-doped sites, enabling precise modulation of their electronic structure. DFT calculations reveal substantial electron transfer from cobalt atoms to surface oxygen groups, which shifts the Co d-band center, reduces the desorption barrier for UA oxidation intermediates, and accelerates the catalytic process. The resulting Co-CN/Ti3CN-modified GCE demonstrates a broad linear detection range and ultralow detection limit. This study establishes an atomic-scale design strategy for electrochemical sensors capable of trace-level UA detection, offering a promising platform for clinical diagnostics and biomedical monitoring.