Scholarlink

<p>Enantioselective C-H functionalization has emerged as an efficient and transformative tool for constructing complex chiral molecules with exceptional step- and atom-economy. While this field was historically dominated by 4d and 5d transition metal catalysts, recent attention has shifted toward cobalt—an earth-abundant, cost-effective 3d transition metal with unique reactivity. Over the past few years, remarkable progress has been achieved in cobalt-catalyzed enantioselective C-H functionalization, primarily through three catalytic systems: (1) low-valent cobalt(I) catalysis, (2) cyclopentadienyl cobalt(III) catalysis, and (3) <i>in situ</i> generated cobalt(III) catalysis. This review provides a comprehensive survey of all reported asymmetric cobalt-catalyzed C-H activations proceeding through inner-sphere mechanisms, providing a systematic analysis of synthetic methodologies, reactivity patterns, origins of stereocontrol, mechanistic insights, and future opportunities.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Earth-abundant cobalt-catalyzed enantioselective C-H functionalizations

  • 期刊论文

  • 发表日期：

    2025年10月15日

查看全文
  • Taixin Yang,
  • Yanbo Zhang,
  • Yingchao Dou,
  • Dandan Yang,
  • Jun-Long Niu

摘要

Enantioselective C-H functionalization has emerged as an efficient and transformative tool for constructing complex chiral molecules with exceptional step- and atom-economy. While this field was historically dominated by 4d and 5d transition metal catalysts, recent attention has shifted toward cobalt—an earth-abundant, cost-effective 3d transition metal with unique reactivity. Over the past few years, remarkable progress has been achieved in cobalt-catalyzed enantioselective C-H functionalization, primarily through three catalytic systems: (1) low-valent cobalt(I) catalysis, (2) cyclopentadienyl cobalt(III) catalysis, and (3) in situ generated cobalt(III) catalysis. This review provides a comprehensive survey of all reported asymmetric cobalt-catalyzed C-H activations proceeding through inner-sphere mechanisms, providing a systematic analysis of synthetic methodologies, reactivity patterns, origins of stereocontrol, mechanistic insights, and future opportunities.