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<p>Triple-negative breast cancer (TNBC), characterized by its aggressive metastasis and resistance to conventional therapies, presents a clinical challenge due to its poor prognosis. In this study, we develop an injectable Gd-Ru heterometallic coordination gel (Gd-RuL<sub>3</sub>) via self-assembly of Gd<sup>3+</sup> and Ru(II)-polypyridyl ligand complexes, which synergistically integrates magnetic resonance imaging (MRI) contrast enhancement for <i>in vivo</i> tumor imaging and efficient photodynamic therapy. Notably, the absorption wavelength of constructed gel exhibits a significant red shift towards a therapeutic window (650–900 nm), enabling deep-tumor photodynamic therapy with greater tissue penetration than conventional Ru(II) photosensitizers. The Gd-RuL<sub>3</sub> gel possesses good capacity for singlet oxygen generation, demonstrating its potential as long-wavelength absorbing photosensitizers for efficient photodynamic therapy that integrates MRI-guided tumor diagnosis. This work provides an innovative approach for designing Ru(II)-based theranostic agents that combine deep-tissue imaging and precision therapy for tumor treatment.</p>

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Long-wavelength absorbing Gd-Ru metal-organic gel for dual-mode MR imaging and photodynamic therapy against triple-negative breast cancer

  • 期刊论文

  • 发表日期：

    2025年9月11日

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  • Yan-Wu Zhao,
  • Fang Zhang,
  • Shao-Zhe Yi,
  • Ya-Ping Wang,
  • Xiao-Hui Duan,
  • Mei Pan,
  • Cheng-Yong Su

摘要

Triple-negative breast cancer (TNBC), characterized by its aggressive metastasis and resistance to conventional therapies, presents a clinical challenge due to its poor prognosis. In this study, we develop an injectable Gd-Ru heterometallic coordination gel (Gd-RuL3) via self-assembly of Gd3+ and Ru(II)-polypyridyl ligand complexes, which synergistically integrates magnetic resonance imaging (MRI) contrast enhancement for in vivo tumor imaging and efficient photodynamic therapy. Notably, the absorption wavelength of constructed gel exhibits a significant red shift towards a therapeutic window (650–900 nm), enabling deep-tumor photodynamic therapy with greater tissue penetration than conventional Ru(II) photosensitizers. The Gd-RuL3 gel possesses good capacity for singlet oxygen generation, demonstrating its potential as long-wavelength absorbing photosensitizers for efficient photodynamic therapy that integrates MRI-guided tumor diagnosis. This work provides an innovative approach for designing Ru(II)-based theranostic agents that combine deep-tissue imaging and precision therapy for tumor treatment.