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<p>The burgeoning field of proximity-inducing modalities has revolutionized antiviral agent development by harnessing the power of molecular proximity to regulate protein-protein or protein-RNA interactions. This review delves into the innovative strategies and breakthroughs in designing antiviral compounds that leverage induced spatial association, a concept with profound implications for both therapeutic applications and fundamental research. We highlight the role of bifunctional molecules in modulating cellular processes to combat viral infections, underscoring their potential within the proximity induction framework. The review encompasses a comprehensive analysis of current applications and future prospects of proximity-inducing molecules in antiviral research, emphasizing their promise for advancing antiviral therapies and infection control strategies.</p>

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Harnessing molecular proximity for antiviral innovations: advances in proximity-inducing modalities against viral infections

  • 期刊论文

  • 发表日期：

    2025年6月24日

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  • Linan Wu,
  • Shujing Xu,
  • Yang Zhou,
  • Dazhou Shi,
  • Mei Wang,
  • Meehyein Kim,
  • Peng Zhan

摘要

The burgeoning field of proximity-inducing modalities has revolutionized antiviral agent development by harnessing the power of molecular proximity to regulate protein-protein or protein-RNA interactions. This review delves into the innovative strategies and breakthroughs in designing antiviral compounds that leverage induced spatial association, a concept with profound implications for both therapeutic applications and fundamental research. We highlight the role of bifunctional molecules in modulating cellular processes to combat viral infections, underscoring their potential within the proximity induction framework. The review encompasses a comprehensive analysis of current applications and future prospects of proximity-inducing molecules in antiviral research, emphasizing their promise for advancing antiviral therapies and infection control strategies.