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<p>Phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), is a promising biotechnological approach for effective tumor treatment. However, the application of phototherapy is seriously compromised by limited tissue penetration of light, inadequate visualization of the real situation of a tumor, and dissatisfied treatment by sole PDT or PTT. In this work, an integrated small molecular (L-CF<sub>3</sub>) is rationally constructed, which is used for the second near-infrared fluorescence (NIR-II FL) and photoacoustic (PA) imaging-guided PDT and PTT of tumors for simultaneously overcoming these obstacles. Compared with the first near-infrared (NIR-I) light, NIR-II light achieves deeper tissue penetration, which enables L-CF<sub>3</sub> with great potential in antitumor phototherapy. Under the irradiation of 1064 nm light, L-CF<sub>3</sub> simultaneously exhibits great photothermal conversion effect and singlet oxygen generation capacity. Furthermore, the intense NIR-II FL and PA signals are also detected after exposure to excitation light. Notably, the nanoparticles loading L-CF<sub>3</sub> (L-CF<sub>3</sub> NPs) exhibit remarkable tumor targeting ability and NIR-II FL/PA imaging-guided complete tumor photoablation, providing a new view in multimode imaging-guided precise NIR-II anticancer phototherapy.</p>

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A cyanine fluorophore for imaging-guided tumor photodynamic and photothermal therapy under NIR-II light activation

  • 期刊论文

  • 发表日期：

    2025年3月10日

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  • Wenkai Liu,
  • Chengyuan Lv,
  • Yanxian Hou,
  • Xue Lou,
  • Zhiyuan Ma,
  • Maomao He,
  • Xiaolong Zeng,
  • Wen Sun,
  • Jiangli Fan,
  • Xiaojun Peng

摘要

Phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), is a promising biotechnological approach for effective tumor treatment. However, the application of phototherapy is seriously compromised by limited tissue penetration of light, inadequate visualization of the real situation of a tumor, and dissatisfied treatment by sole PDT or PTT. In this work, an integrated small molecular (L-CF3) is rationally constructed, which is used for the second near-infrared fluorescence (NIR-II FL) and photoacoustic (PA) imaging-guided PDT and PTT of tumors for simultaneously overcoming these obstacles. Compared with the first near-infrared (NIR-I) light, NIR-II light achieves deeper tissue penetration, which enables L-CF3 with great potential in antitumor phototherapy. Under the irradiation of 1064 nm light, L-CF3 simultaneously exhibits great photothermal conversion effect and singlet oxygen generation capacity. Furthermore, the intense NIR-II FL and PA signals are also detected after exposure to excitation light. Notably, the nanoparticles loading L-CF3 (L-CF3 NPs) exhibit remarkable tumor targeting ability and NIR-II FL/PA imaging-guided complete tumor photoablation, providing a new view in multimode imaging-guided precise NIR-II anticancer phototherapy.