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<p>Diabetic wound healing remains a major challenge due to the excess hyperglycemia microenvironment, massively bacterial infections, macrophage dysfunction, and persistent inflammation. To comprehensively solve these problems, novel multifunctional materials are highly desirable. Herein, a versatile and intelligent hydrogel (Cu<sub>2</sub>S@FePPOP<sub>TPM</sub>@GOx@Gel) is reported. Cu<sub>2</sub>S@FePPOP<sub>TPM</sub>@GOx with hollow morphology and controllable size was rationally designed and fabricated by using Cu<sub>2</sub>S nanocubes as a template, followed by <i>in situ</i> growth of FePPOP<sub>TPM</sub> and loading glucose oxidase (GOx), successively. When infection occurs, the Schiff base bonds in Cu<sub>2</sub>S@FePPOP<sub>TPM</sub>@GOx@Gel can controllably release Cu<sub>2</sub>S@FePPOP<sub>TPM</sub>@GOx based on its excellent dynamic pH-responsiveness, thereby synergically reducing blood glucose levels and killing bacteria achieved relying on the excellent catalytic activity of GOx towards glucose and its promoted peroxidelike activity of FePPOP<sub>TPM</sub>. Further experiments on diabetic wound model <i>in vivo</i> demonstrated that Cu<sub>2</sub>S@FePPOP<sub>TPM</sub>@GOx@Gel promoted wound healing and skin regeneration, which was attributed to its antibacterial properties, alleviating inflammation, stimulating vascular regeneration, and encouraging M2 polarization of macrophages. This work provides a novel strategy for the construction of a microenvironment-responsive and antibiotics-free drug delivery platform to treat diabetic wounds, as well as broad prospects of nanomaterials in the clinical treatment of chronic wounds.</p>

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Nanoscale and hollow inorganic sulfide@porous organic network doped intelligent hydrogels for accelerating diabetes wound therapeutics

  • 期刊论文

  • 发表日期：

    2025年1月14日

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  • Yanhong Li,
  • Qiang Zhang,
  • Quanbo Wang,
  • Junping Wang,
  • Xiaomei Zhang,
  • Caixia Yin

摘要

Diabetic wound healing remains a major challenge due to the excess hyperglycemia microenvironment, massively bacterial infections, macrophage dysfunction, and persistent inflammation. To comprehensively solve these problems, novel multifunctional materials are highly desirable. Herein, a versatile and intelligent hydrogel (Cu2S@FePPOPTPM@GOx@Gel) is reported. Cu2S@FePPOPTPM@GOx with hollow morphology and controllable size was rationally designed and fabricated by using Cu2S nanocubes as a template, followed by in situ growth of FePPOPTPM and loading glucose oxidase (GOx), successively. When infection occurs, the Schiff base bonds in Cu2S@FePPOPTPM@GOx@Gel can controllably release Cu2S@FePPOPTPM@GOx based on its excellent dynamic pH-responsiveness, thereby synergically reducing blood glucose levels and killing bacteria achieved relying on the excellent catalytic activity of GOx towards glucose and its promoted peroxidelike activity of FePPOPTPM. Further experiments on diabetic wound model in vivo demonstrated that Cu2S@FePPOPTPM@GOx@Gel promoted wound healing and skin regeneration, which was attributed to its antibacterial properties, alleviating inflammation, stimulating vascular regeneration, and encouraging M2 polarization of macrophages. This work provides a novel strategy for the construction of a microenvironment-responsive and antibiotics-free drug delivery platform to treat diabetic wounds, as well as broad prospects of nanomaterials in the clinical treatment of chronic wounds.