<p>This paper studies the consensus tracking control of networked stochastic leader-following multi-agent systems (MASs) with multiplicative and additive time-varying actuator failures under random communication topology switching. Considering the measurement noise generated by information transmission in networked systems, the stochastic MASs model with multiplicative noise is established. Meanwhile, the random time-varying loss of actuator effectiveness failure and bias faults are taken into account. Based on the neighbors’ and leaders’ state, the distributed adaptive fault-tolerant consensus tracking control protocols are proposed under the case of Markovian and semi-Markovian switching topology. Using stochastic system theory and Lyapunov theorem, sufficient conditions of the mean-square practical stability for leader-following consensus tracking are obtained. Results show that under the proposed distributed adaptive fault-tolerant control (DAFTC) protocols, the follower agents can track the leader under actuator constrains and random switching topology. Finally, the effectiveness of the mentioned control protocols are verified the numerical simulations.</p>