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<p>Two new mycobactins, U (<b>1</b>) and V (<b>3</b>), were isolated with ferric-<b>1</b> (<b>2</b>) and ferric-<b>3</b> (<b>4</b>) from the culture extracts of <i>Mycolicibacterium septicum</i> IFM 12283. The structures of compounds <b>1</b>–<b>4</b> were elucidated via spectral studies, including various NMR analyses. The absolute configurations of compounds <b>1</b>–<b>4</b> were deduced by comparing their circular dichroism (CD) spectra with those of mycobactin H (<b>5</b>) and ferric-mycobactin H (<b>6</b>). These compounds exhibited cytotoxicity against the MH7A rheumatoid fibroblast-like synovial cell line.</p> Graphical abstract <p></p>

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Two new mycobactins, mycobactins U and V, and their ferric complexes isolated from Mycolicibacterium septicum IFM 12283

  • 期刊论文

  • 发表日期：

    2026年2月3日

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  • Yasumasa Hara,
  • Yuki Matsuoka,
  • Akiko Takaya,
  • Masami Ishibashi

摘要

Two new mycobactins, U (1) and V (3), were isolated with ferric-1 (2) and ferric-3 (4) from the culture extracts of Mycolicibacterium septicum IFM 12283. The structures of compounds 1–4 were elucidated via spectral studies, including various NMR analyses. The absolute configurations of compounds 1–4 were deduced by comparing their circular dichroism (CD) spectra with those of mycobactin H (5) and ferric-mycobactin H (6). These compounds exhibited cytotoxicity against the MH7A rheumatoid fibroblast-like synovial cell line.

Graphical abstract