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<p>A phytochemical investigation of the twigs and stems of <i>Dalbergia cultrata</i> yielded fourteen secondary metabolites, including three novel compounds: two neoflavonoids and a megastigmane glycoside. Structures were elucidated using spectroscopic methods and ECD calculations. Biological evaluation showed weak to moderate antibacterial and antioxidant activities, whereas aromatase inhibition was more pronounced. Two coumarins, dalbergin (<b>11</b>) and stevenin (<b>12</b>), were the most potent inhibitors, with IC₅₀ values of 1.23 and 1.61 µM, respectively. In contrast, the selected neoflavonoids showed only moderate activity. Neoflavonoid <b>7</b> exhibited both growth-inhibitory and fungicidal activity against <i>Candida albicans</i> and <i>C. tropicalis</i>. These results highlight <i>D. cultrata</i> as a source of structurally diverse and biologically active secondary metabolites.</p> Graphical abstract <p></p>

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Neoflavonoids and a megastigmane glycoside from Dalbergia cultrata: structural elucidation and biological evaluation

  • 期刊论文

  • 发表日期：

    2026年3月15日

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  • Wiriya Yaosanit,
  • Paratchata Batsomboon,
  • Phanruethai Pailee,
  • Theerawat Thananthaisong,
  • Poonsakdi Ploypradith,
  • Somkid Sitthimonchai,
  • Wansuda Sutinan,
  • Panita Khlaychan,
  • Chulabhorn Mahidol,
  • Supanna Techasakul,
  • Somsak Ruchirawat,
  • Vilailak Prachyawarakorn

摘要

A phytochemical investigation of the twigs and stems of Dalbergia cultrata yielded fourteen secondary metabolites, including three novel compounds: two neoflavonoids and a megastigmane glycoside. Structures were elucidated using spectroscopic methods and ECD calculations. Biological evaluation showed weak to moderate antibacterial and antioxidant activities, whereas aromatase inhibition was more pronounced. Two coumarins, dalbergin (11) and stevenin (12), were the most potent inhibitors, with IC₅₀ values of 1.23 and 1.61 µM, respectively. In contrast, the selected neoflavonoids showed only moderate activity. Neoflavonoid 7 exhibited both growth-inhibitory and fungicidal activity against Candida albicans and C. tropicalis. These results highlight D. cultrata as a source of structurally diverse and biologically active secondary metabolites.

Graphical abstract