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<p>Two new cerebrosides leptasteriacerebroside A (<b>1</b>) and B (<b>2</b>) were isolated from the starfish <i>Leptasterias polaris acervata</i>, together with two known ones (2<i>S</i>,3<i>R</i>,4<i>E</i>,9<i>Z</i>)-1-<i>O</i>-(β-D-glucopyranosyl)-2-[(2<i>R</i>)-2-hydroxyhexadecanoylamino]-4,9-docosadien-3-ol (<b>3</b>) and astrocerebroside B (<b>4</b>). The structures of the isolated compounds were characterized using spectroscopic techniques HRESIMS, ESIMS/MS, 1D and 2D NMR as well as by chemical modification and subsequent analysis of derivatives. The antimicrobial, urease inhibitory, cytotoxic, and cytoprotective activities of compounds <b>1</b>–<b>4</b> were investigated. Notably, compound <b>1</b> exhibited significant protection of H9c2 cardiomyocytes against CoCl<sub>2</sub>-induced toxicity, while compounds <b>2</b> and <b>4</b> demonstrated efficacy in mitigating TNF-α-mediated cytotoxicity, likely through inhibition of the NF-κB-dependent inflammatory pathway.</p> Graphical abstract <p></p>

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New cerebrosides from the polar starfish Leptasterias polaris acervata and their cardioprotective and anti-inflammatory activity

  • 期刊论文

  • 发表日期：

    2026年2月3日

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  • Viktor M. Zakharenko,
  • Timofey V. Malyarenko,
  • Alla A. Kicha,
  • Anatoly I. Kalinovsky,
  • Roman S. Popov,
  • Ekaterina A. Chingizova,
  • Ekaterina A. Yurchenko,
  • Natalia V. Ivanchina

摘要

Two new cerebrosides leptasteriacerebroside A (1) and B (2) were isolated from the starfish Leptasterias polaris acervata, together with two known ones (2S,3R,4E,9Z)-1-O-(β-D-glucopyranosyl)-2-[(2R)-2-hydroxyhexadecanoylamino]-4,9-docosadien-3-ol (3) and astrocerebroside B (4). The structures of the isolated compounds were characterized using spectroscopic techniques HRESIMS, ESIMS/MS, 1D and 2D NMR as well as by chemical modification and subsequent analysis of derivatives. The antimicrobial, urease inhibitory, cytotoxic, and cytoprotective activities of compounds 1–4 were investigated. Notably, compound 1 exhibited significant protection of H9c2 cardiomyocytes against CoCl2-induced toxicity, while compounds 2 and 4 demonstrated efficacy in mitigating TNF-α-mediated cytotoxicity, likely through inhibition of the NF-κB-dependent inflammatory pathway.

Graphical abstract