Scholarlink

<p>New <i>seco</i>-apotirucallane triterpenoids, pachyphylinin A (<b>1</b>) and B (<b>2</b>), were isolated from the stem bark of <i>Aglaia pachyphylla</i> alongside nine triterpenoid compounds (<b>3</b>–<b>11</b>). The structures were elucidated and identified through various spectroscopic analyses, including 1D and 2D NMR, HRTOF-MS, FTIR, as well as ECD, complemented by computational calculation using TD-DFT. In the process, pachyphylinin A (<b>1</b>) and B (<b>2</b>) were tested for cytotoxic activity against the breast cancer cell line (MCF-7). The results showed cytotoxic activities against MCF-7 with IC<sub>50</sub> values in the range of 98.8–500 µM.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Pachyphylinin A-B: two novel seco-apotirucallane triterpenoids with cytotoxic activities from the stem bark of Aglaia pachyphylla

  • 期刊论文

  • 发表日期：

    2025年12月24日

查看全文
  • Wahyu Safriansyah,
  • Erina Hilmayanti,
  • Rustaman,
  • Kindi Farabi,
  • Mohamad Azlan Nafiah,
  • Mohamad Nurul Azmi,
  • Sofa Fajriah,
  • Kazuya Kabayama,
  • Atsushi Shimoyama,
  • Yoshiyuki Manabe,
  • Koichi Fukase,
  • Hadi Kuncoro,
  • Unang Supratman,
  • Desi Harneti

摘要

New seco-apotirucallane triterpenoids, pachyphylinin A (1) and B (2), were isolated from the stem bark of Aglaia pachyphylla alongside nine triterpenoid compounds (3–11). The structures were elucidated and identified through various spectroscopic analyses, including 1D and 2D NMR, HRTOF-MS, FTIR, as well as ECD, complemented by computational calculation using TD-DFT. In the process, pachyphylinin A (1) and B (2) were tested for cytotoxic activity against the breast cancer cell line (MCF-7). The results showed cytotoxic activities against MCF-7 with IC50 values in the range of 98.8–500 µM.

Graphical abstract