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<p>Two new prunasines, bachmasides A and B (<b>1–2</b>), together with five known compounds, methyl 6-<i>O</i>-<i>p</i>-<i>trans</i>-coumaroyl-<i>β</i>-<span>d</span>-glucopyranoside (<b>3</b>), methyl 6-<i>O</i>-feruloyl-<i>β</i>-<span>d</span>-glucopyranoside (<b>4</b>), polystachyol (<b>5</b>), ethyl (6-<i>O</i>-<i>p</i>-hydroxybenzoyl)-<i>β</i>-<span>d</span>-glucopyranoside (<b>6</b>), and prunasin (<b>7</b>) were isolated from leaves of <i>Elaeocarpus bachmaensis</i>. The structures of isolated compounds (<b>1</b>–<b>7</b>) were elucidated by 1D-NMR, 2D-NMR, and HRMS spectra. The inhibition assays showed that compound <b>5</b> significantly inhibited α-amylase with IC<sub>50</sub> value of 90.2 ± 11.5&#xa0;µg/ml, whereas compounds <b>1</b>,<b> 2</b>, <b>4</b> and <b>6</b> significantly inhibited α-glucosidase with IC<sub>50</sub> values ranging from 42.4 ± 5.4 to 75.4 ± 5.6&#xa0;µg/ml, considerably lower than those of acarbose (IC<sub>50</sub> of 112.1 ± 3.1 and 133.0 ± 4.4&#xa0;µg/ml, respectively). These findings suggest that <i>E. bachmaensis</i> may be a promising source of antidiabetic agents.</p> Graphical abstract <p></p>

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New prunasin derivatives, bachmasides A and B, with α-glucosidase inhibitory activity from the leaves of Elaeocarpus bachmaensis

  • 期刊论文

  • 发表日期：

    2025年10月17日

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  • Phan Thi Diem Tran,
  • Vu Thi Thanh Tam,
  • Tran Phuong Ha,
  • Le Tuan Anh,
  • Le Trung Hieu,
  • Ton That Huu Dat,
  • Le Canh Viet Cuong

摘要

Two new prunasines, bachmasides A and B (1–2), together with five known compounds, methyl 6-O-p-trans-coumaroyl-β-d-glucopyranoside (3), methyl 6-O-feruloyl-β-d-glucopyranoside (4), polystachyol (5), ethyl (6-O-p-hydroxybenzoyl)-β-d-glucopyranoside (6), and prunasin (7) were isolated from leaves of Elaeocarpus bachmaensis. The structures of isolated compounds (1–7) were elucidated by 1D-NMR, 2D-NMR, and HRMS spectra. The inhibition assays showed that compound 5 significantly inhibited α-amylase with IC50 value of 90.2 ± 11.5 µg/ml, whereas compounds 1, 2, 4 and 6 significantly inhibited α-glucosidase with IC50 values ranging from 42.4 ± 5.4 to 75.4 ± 5.6 µg/ml, considerably lower than those of acarbose (IC50 of 112.1 ± 3.1 and 133.0 ± 4.4 µg/ml, respectively). These findings suggest that E. bachmaensis may be a promising source of antidiabetic agents.

Graphical abstract