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<p>Two new (<b>1</b>–<b>2</b>) and eight known pterosins (<b>3</b>–<b>10</b>) were obtained from the aerial parts of <i>Hypolepis punctata</i>. One compound (<b>11</b>) was synthesized from compound <b>4</b>. Their structures were established by spectroscopic methods and the absolute configuration was further determined by single-crystal X-ray diffraction analysis for compounds <b>1</b>, <b>3</b> and <b>4</b>. Notably, compound <b>1</b> showed low toxicity while significantly inhibiting lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells.</p> Graphical abstract <p></p>

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New pterosins from Hypolepis punctata

  • 期刊论文

  • 发表日期：

    2025年9月8日

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  • Liang Shen,
  • Wenhao Mu,
  • Peixin Wang,
  • Maoni Ren,
  • Yating Jia,
  • Xiaoran Min,
  • Jiajia He,
  • Guozheng Huang,
  • Hui Shen,
  • Jianguo Cao

摘要

Two new (1–2) and eight known pterosins (3–10) were obtained from the aerial parts of Hypolepis punctata. One compound (11) was synthesized from compound 4. Their structures were established by spectroscopic methods and the absolute configuration was further determined by single-crystal X-ray diffraction analysis for compounds 1, 3 and 4. Notably, compound 1 showed low toxicity while significantly inhibiting lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells.

Graphical abstract