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<p>Eight chlorinated illudalane sesquiterpenoids were isolated from the aerial parts of <i>Saxiglossum angustissimum</i>, including a pair of new pterosin enantiomers, (2<i>R</i>)-angupterosin (<b>1</b>) and (2<i>S</i>)-angupterosin (<b>2</b>), as well as a new pteroside, angupteroside (<b>3</b>). The structures of these compounds were determined through comprehensive analysis of HRESI-MS, NMR spectral data, ECD, and comparisons with previously reported literature. Remarkably, these chlorine-containing compounds (<b>1</b>–<b>8</b>) are rare and represent the first discovery of such metabolites within the family Pyrrosioideae. The chlorinated illudalane sesquiterpenoids from <i>S. angustissimum</i> may serve as valuable chemotaxonomic markers for this species. Furthermore, compounds <b>1</b>–<b>8</b> demonstrated inhibitory effects on LPS-induced NO release in BV2 cells, highlighting their potential anti-inflammatory properties.</p> Graphical abstract <p></p>

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Chlorinated illudalane sequiterpenoids from Saxiglossum angustissimum

  • 期刊论文

  • 发表日期：

    2025年5月9日

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  • Yu-ting Chen,
  • Jian-hua Hong,
  • Cai-ying Peng,
  • Jian-qun Liu,
  • Yu-ye Zhu,
  • Ji-cheng Shu

摘要

Eight chlorinated illudalane sesquiterpenoids were isolated from the aerial parts of Saxiglossum angustissimum, including a pair of new pterosin enantiomers, (2R)-angupterosin (1) and (2S)-angupterosin (2), as well as a new pteroside, angupteroside (3). The structures of these compounds were determined through comprehensive analysis of HRESI-MS, NMR spectral data, ECD, and comparisons with previously reported literature. Remarkably, these chlorine-containing compounds (1–8) are rare and represent the first discovery of such metabolites within the family Pyrrosioideae. The chlorinated illudalane sesquiterpenoids from S. angustissimum may serve as valuable chemotaxonomic markers for this species. Furthermore, compounds 1–8 demonstrated inhibitory effects on LPS-induced NO release in BV2 cells, highlighting their potential anti-inflammatory properties.

Graphical abstract