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<p>Two new abietane-type diterpenoids, 6<i>β</i>-(3-furoyloxy)ferruginol (<b>1</b>) and 6-chloro-6,7-dehydroferruginol (<b>2</b>), were isolated from the roots of <i>Euonymus hamiltonianus</i> along with five known diterpenoids (<b>3</b>–<b>7</b>). Their structures were characterized using various spectroscopic analysis including HRMS, 1D and 2D NMR, and ECD analysis. All isolated compounds (<b>1</b>–<b>7</b>) were evaluated for their cytotoxic activity against human colon cancer cell line, HCT116, and it was found to exhibit moderate cytotoxic activity with IC<sub>50</sub> values ranging from 4.5 to 22.9&#xa0;μM. Among the isolated compounds, montbretol (<b>4</b>) displayed the most cytotoxic activity (IC<sub>50</sub> = 4.50 ± 0.29&#xa0;μM) against HCT116 human colon cancer cells than the other isolated compounds.</p> Graphical abstract <p></p>

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New abietane-type diterpenoids from roots of Euonymus hamiltonianus and their cytotoxicity in human cancer cell

  • 期刊论文

  • 发表日期：

    2025年3月1日

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  • Jungmoo Huh,
  • Eun Jin Park,
  • Jae Hyun Lee,
  • Chan-Woong Park,
  • Tae-Jin Yang,
  • Won Keun Oh,
  • Young-Won Chin

摘要

Two new abietane-type diterpenoids, 6β-(3-furoyloxy)ferruginol (1) and 6-chloro-6,7-dehydroferruginol (2), were isolated from the roots of Euonymus hamiltonianus along with five known diterpenoids (3–7). Their structures were characterized using various spectroscopic analysis including HRMS, 1D and 2D NMR, and ECD analysis. All isolated compounds (1–7) were evaluated for their cytotoxic activity against human colon cancer cell line, HCT116, and it was found to exhibit moderate cytotoxic activity with IC50 values ranging from 4.5 to 22.9 μM. Among the isolated compounds, montbretol (4) displayed the most cytotoxic activity (IC50 = 4.50 ± 0.29 μM) against HCT116 human colon cancer cells than the other isolated compounds.

Graphical abstract