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<p><i>Boletus bicolor</i> is a kind of wild edible boletus, which is widely distributed in China. We have isolated the protein D1 from <i>B. bicolor</i>, and found that protein D1 has a significant inhibitory effect on the growth and proliferation of lung cancer A549 cells both in vitro and in vivo. In this paper, we found that miR-34a plays an important role in inhibiting the proliferation of A549 cells. miR-34a is the functional target of protein D1 against A549 cells. Protein D1 induces the positive feedback regulation of miR-34a and p53, which further regulates downstream Bcl-2 and CDK6, and inhibits the proliferation of A549 cells.</p> Graphical Abstract <p></p>

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Fungal protein D1 inhibits the proliferation of A549 cells via activating the p53/miR-34a signaling pathway

  • 期刊论文

  • 发表日期：

    2025年2月18日

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  • Min-Hui Zhang,
  • Fang Liu,
  • Wen-Hui Gao,
  • Zhao-Kun Liu

摘要

Boletus bicolor is a kind of wild edible boletus, which is widely distributed in China. We have isolated the protein D1 from B. bicolor, and found that protein D1 has a significant inhibitory effect on the growth and proliferation of lung cancer A549 cells both in vitro and in vivo. In this paper, we found that miR-34a plays an important role in inhibiting the proliferation of A549 cells. miR-34a is the functional target of protein D1 against A549 cells. Protein D1 induces the positive feedback regulation of miR-34a and p53, which further regulates downstream Bcl-2 and CDK6, and inhibits the proliferation of A549 cells.

Graphical Abstract