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<p>This study aimed to develop a laboratory-based&#xa0;frailty&#xa0;index (FI-Lab) to predict 12-month mortality risk in elderly patients following a hip fracture (HF). A retrospective analysis of 235 consecutive patients over 70&#xa0;years old, who underwent HF surgery, was conducted. The FI-Lab, based on 21 routine blood parameters, was evaluated using Receiver Operating Characteristics, Area Under the Curve (AUC), Kaplan–Meier curves, and Cox proportional Hazard ratios. The FI-Lab showed an AUC of 0.7177 for 6-month and 0.7423 for 1-year survival. High FI-Lab values correlated with higher preoperative ASA scores, longer time-to-surgery times, more perioperative transfusions, and higher postoperative complication rates. The Cox hazard ratio revealed a significant increase in the risk of death for 1&#xa0;year and 6&#xa0;months from a score of 0.4 and higher. These findings highlight the FI-Lab’s clinical relevance and validity as a predictive tool, emphasizing the need for differentiated perioperative risk stratification.</p>

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Development of a laboratory-based frailty index for risk prediction in elderly trauma patients with hip fractures

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月17日

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  • Malou-Sophie Dietrich,
  • Emmanouil Liodakis,
  • Stephan Sehmisch,
  • Marcel Winkelmann,
  • Manfred Gogol

摘要

This study aimed to develop a laboratory-based frailty index (FI-Lab) to predict 12-month mortality risk in elderly patients following a hip fracture (HF). A retrospective analysis of 235 consecutive patients over 70 years old, who underwent HF surgery, was conducted. The FI-Lab, based on 21 routine blood parameters, was evaluated using Receiver Operating Characteristics, Area Under the Curve (AUC), Kaplan–Meier curves, and Cox proportional Hazard ratios. The FI-Lab showed an AUC of 0.7177 for 6-month and 0.7423 for 1-year survival. High FI-Lab values correlated with higher preoperative ASA scores, longer time-to-surgery times, more perioperative transfusions, and higher postoperative complication rates. The Cox hazard ratio revealed a significant increase in the risk of death for 1 year and 6 months from a score of 0.4 and higher. These findings highlight the FI-Lab’s clinical relevance and validity as a predictive tool, emphasizing the need for differentiated perioperative risk stratification.