Scholarlink

<p>HealthAge was devised by a conglomerate of research groups in Toulouse, France, with the combined goal of narrowing the lifespan-healthspan gap through novel translational bench-to-bedside research studies. HealthAge comprises the “INStitute for Prevention” “healthy aging” and “medicine Rejuvenative” (INSPIRE) human translational, outbred SWISS mice and African turquoise killifish (GRZ strain) cohorts in which aging is studied based on the concept of intrinsic capacity (IC). In this narrative review, we describe the three INSPIRE aging models (human cohort, <i>n</i> = 1109, age range 20&#xa0;–102&#xa0;years old with mean age ± standard deviation, 62.4 ± 19.0&#xa0;years and 61.9% female; outbred SWISS mice, <i>n</i> = 1576 and African Turquoise killifish, <i>n</i> = 300) and explain how IC is assessed at the clinical (in humans) and biological level over time. HealthAge strives to elucidate the underlying biology of IC and to identify biomarkers of IC declines and novel gero-therapeutics using the clinical and biological data and biospecimens collected prospectively in the three species. The data sharing policy will foster scientific discovery through new multi-disciplinary collaborations. Thus, HealthAge will promote healthy aging using a unique translational platform based on IC phenotyping with the ultimate goal of preventing loss of human independence and alleviating health costs associated with an aging population.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

HealthAge: evaluation of intrinsic capacity changes in humans, mice, and killifish to explore the biology of aging

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月16日

查看全文
  • Sophie Guyonnet,
  • Claudie Hooper,
  • Heike A. Bischoff-Ferrari,
  • Angelo Parini,
  • Yohan Santin,
  • Jean-Philippe Pradère,
  • Cédric Dray,
  • Bruno Vellas,
  • Sophie Guyonnet,
  • Bruno Vellas,
  • Lauréane Brigitte,
  • Agathe Milhet,
  • Elodie Paez,
  • Emeline Muller,
  • Sabine Le Floch,
  • Catherine Takeda,
  • Catherine Faisant,
  • Françoise Lala,
  • Gabor Abellan Van Kan,
  • Zara Steinmeyer,
  • Antoine Piau,
  • Tony Macaron,
  • Davide Angioni,
  • Pierre-Jean Ousset,
  • Mélanie Comté,
  • Nathalie Daniaud,
  • Fanny Boissou-Parachaud,
  • Sandrine Andrieu,
  • Christelle Cantet,
  • Yves Rolland,
  • Philipe de Souto Barreto,
  • Fabien Pillard,
  • Bernard Teysseyre,
  • Marie Faruch,
  • Pierre Payoux,
  • Neda Tavassoli,
  • Marie Dorard,
  • Bénédicte Razat,
  • Camille Champigny,
  • Angelo Parini,
  • Jean-Philippe Pradère,
  • Yohan Santin,
  • Dominique Langin,
  • Pierre Gourdy,
  • Laurent O. Martinez,
  • Anne Bouloumié,
  • Nicolas Fazilleau,
  • Roland Liblau,
  • Jean-Charles Guéry,
  • Michel Simon,
  • Nicolas Gaudenzio,
  • Luciana Bostan,
  • Hicham El Costa,
  • Nabila Jabrane Ferrat,
  • Philippe Valet,
  • Cedric Dray,
  • Isabelle Ader,
  • Valérie Planat,
  • Louis Casteilla,
  • Patrice Peran,
  • Cyrille Delpierre,
  • Claire Rampon,
  • Noelie Davezac,
  • Bruno Guiard,
  • Nathalie Vergnolle,
  • Jean-Paul Motta,
  • Sara Djebali,
  • Pauline Floch,
  • Céline Deraison,
  • Chrystelle Bonnart,
  • Jean-Emmanuel Sarry,
  • Nicola Coley,
  • Jessica Pontary

摘要

HealthAge was devised by a conglomerate of research groups in Toulouse, France, with the combined goal of narrowing the lifespan-healthspan gap through novel translational bench-to-bedside research studies. HealthAge comprises the “INStitute for Prevention” “healthy aging” and “medicine Rejuvenative” (INSPIRE) human translational, outbred SWISS mice and African turquoise killifish (GRZ strain) cohorts in which aging is studied based on the concept of intrinsic capacity (IC). In this narrative review, we describe the three INSPIRE aging models (human cohort, n = 1109, age range 20 –102 years old with mean age ± standard deviation, 62.4 ± 19.0 years and 61.9% female; outbred SWISS mice, n = 1576 and African Turquoise killifish, n = 300) and explain how IC is assessed at the clinical (in humans) and biological level over time. HealthAge strives to elucidate the underlying biology of IC and to identify biomarkers of IC declines and novel gero-therapeutics using the clinical and biological data and biospecimens collected prospectively in the three species. The data sharing policy will foster scientific discovery through new multi-disciplinary collaborations. Thus, HealthAge will promote healthy aging using a unique translational platform based on IC phenotyping with the ultimate goal of preventing loss of human independence and alleviating health costs associated with an aging population.