Scholarlink

<p>The protective role of dietary vitamin D intake on cognitive function is of interest, but evidence remains inconsistent. We aimed to evaluate the association between dietary vitamin D intake and 2-year cognitive changes in older adults at risk of cognitive decline. This longitudinal study comprised 5454 individuals (aged 55–75&#xa0;years in men and 60–75&#xa0;years in women) who exhibited overweight/obesity and metabolic syndrome. Data on dietary vitamin D intake was assessed using a validated 143-item food frequency questionnaire. Cognitive function was assessed through five composite scores derived from a comprehensive battery of eight neuropsychological tests, encompassing global cognitive function, general cognitive function, attention, executive function, and language domains. Multivariable-adjusted linear regression models were fitted to examine the association between energy-adjusted cumulative average dietary vitamin D intake over time and 2-year changes in cognitive function. After adjusting for multiple covariates, energy-adjusted cumulative average dietary vitamin D intake as a continuous variable was associated with greater 2-year improvements in global cognitive function (<i>β</i> 1.18 × 10<sup>−2</sup>; 95% CI 0.19 × 10<sup>−2</sup> to 2.17 × 10<sup>−2</sup>), executive function (<i>β</i> 1.12 × 10<sup>−2</sup>; 95% CI 0.03 × 10<sup>−2</sup> to 2.21 × 10<sup>−2</sup>), and language (<i>β</i> 1.61 × 10<sup>−2</sup>; 95% CI 0.43 × 10<sup>−2</sup> to 2.78 × 10<sup>−2</sup>). Additionally, the higher cumulative average dietary vitamin D intake quartile was associated with an increase in global cognitive function (<i>β</i> 7.10 × 10<sup>−2</sup>; 95% CI 0.59 × 10<sup>−2</sup> to 13.6 × 10<sup>−2</sup>), language (<i>β</i> 7.07 × 10<sup>−2</sup>; 95% CI − 0.52 × 10<sup>−2</sup> to 14.7 × 10<sup>−2</sup>), and a lower decline in attention (<i>β</i> 9.58 × 10<sup>−2</sup>; 95% CI 1.60 × 10<sup>−2</sup> to 17.5 × 10<sup>−2</sup>). A higher dietary vitamin D intake was associated with modest favorable changes in cognitive function and a reduced cognitive decline over a 2-year period. These findings highlight the need for further research to explore the potential benefits of boosting dietary vitamin D intake for cognitive health in older adults.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Dietary vitamin D intake and 2-year changes in cognitive function in older adults with overweight or obesity and metabolic syndrome

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月6日

查看全文
  • Héctor Vázquez-Lorente,
  • Jiaqi Ni,
  • Indira Paz-Graniel,
  • Estefanía Toledo,
  • Dolores Corella,
  • Olga Castañer,
  • J. Alfredo Martínez,
  • Ángel M. Alonso-Gómez,
  • Julia Wärnberg,
  • Jesús Vioque,
  • Dora Romaguera,
  • José López-Miranda,
  • Ramon Estruch,
  • Francisco J. Tinahones,
  • José Lapetra,
  • Lluís Serra-Majem,
  • Amira Bouzalmate-Hajjaj,
  • Josep A. Tur,
  • Rafael M. Micó Pérez,
  • Marta Fanlo,
  • Miguel Delgado-Rodríguez,
  • Ana Barabash Bustelo,
  • Josep Vidal,
  • Clotilde Vázquez,
  • Lidia Daimiel,
  • Emili Ros,
  • Fernando Fernández-Aranda,
  • Teresa Rognoni,
  • Nancy Babio,
  • Eva M. Asensio,
  • Karla-Alejandra Pérez-Vega,
  • Antonio Garcia-Rios,
  • Laura Compañ-Gabucio,
  • Raquel Cueto-Galán,
  • M. Angeles Zulet,
  • Mar Nafria,
  • Rosa Casas,
  • Naomi Cano-Ibáñez,
  • Luis Tojal-Sierra,
  • Ana María Gómez-Pérez,
  • Nuria Goñi,
  • José V. Sorli,
  • María Dolores Zomeño,
  • Antonio P. Arenas-Larriva,
  • Pedro Jiménez-Sellés,
  • Javier Basterra-Gortari,
  • Montserrat Fitó,
  • Jordi Salas-Salvadó

摘要

The protective role of dietary vitamin D intake on cognitive function is of interest, but evidence remains inconsistent. We aimed to evaluate the association between dietary vitamin D intake and 2-year cognitive changes in older adults at risk of cognitive decline. This longitudinal study comprised 5454 individuals (aged 55–75 years in men and 60–75 years in women) who exhibited overweight/obesity and metabolic syndrome. Data on dietary vitamin D intake was assessed using a validated 143-item food frequency questionnaire. Cognitive function was assessed through five composite scores derived from a comprehensive battery of eight neuropsychological tests, encompassing global cognitive function, general cognitive function, attention, executive function, and language domains. Multivariable-adjusted linear regression models were fitted to examine the association between energy-adjusted cumulative average dietary vitamin D intake over time and 2-year changes in cognitive function. After adjusting for multiple covariates, energy-adjusted cumulative average dietary vitamin D intake as a continuous variable was associated with greater 2-year improvements in global cognitive function (β 1.18 × 10−2; 95% CI 0.19 × 10−2 to 2.17 × 10−2), executive function (β 1.12 × 10−2; 95% CI 0.03 × 10−2 to 2.21 × 10−2), and language (β 1.61 × 10−2; 95% CI 0.43 × 10−2 to 2.78 × 10−2). Additionally, the higher cumulative average dietary vitamin D intake quartile was associated with an increase in global cognitive function (β 7.10 × 10−2; 95% CI 0.59 × 10−2 to 13.6 × 10−2), language (β 7.07 × 10−2; 95% CI − 0.52 × 10−2 to 14.7 × 10−2), and a lower decline in attention (β 9.58 × 10−2; 95% CI 1.60 × 10−2 to 17.5 × 10−2). A higher dietary vitamin D intake was associated with modest favorable changes in cognitive function and a reduced cognitive decline over a 2-year period. These findings highlight the need for further research to explore the potential benefits of boosting dietary vitamin D intake for cognitive health in older adults.