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<p>Anthocyanins are dietary flavonoids shown to have a therapeutic capacity to mitigate inflammation and oxidative stress. The present secondary analyses from the “Anthocyanins in People at Risk for Dementia Study” were aimed at (I) determining the intervention’s effect on blood-based markers of cardiovascular disease and inflammation and (II) evaluating whether baseline factors such as age, sex, inflammation, or cardiometabolic score may moderate the intervention’s effect on inflammatory status. This study was an ancillary, 24-week randomized, double-blind, placebo-controlled Phase II trial. Sub-sample participants (<i>n</i> = 99), aged 60–80&#xa0;years with mild cognitive impairment or cardiometabolic disorders, were randomized to receive either 320&#xa0;mg/day of anthocyanins or placebo. The biomarkers analyzed included inflammatory biomarker assessment (IL − 6, IL − 8, IL − 10, IL − 1b, TNF − α, IFN − γ), and C-reactive protein (CRP), as well as albumin, thrombocytes, cholesterol, LDL, HDL, and triglycerides, which were longitudinally compared between both groups. Baseline characteristics were balanced between the groups. ANCOVA analyses reveal 24-week differences favoring the anthocyanin treatment in LDL cholesterol levels (ƞp<sup>2</sup> = 0.078; <i>p</i> = 0.015), cardiometabolic score (ƞp<sup>2</sup> = 0.073; <i>p</i> = 0.021), CRP levels (ƞp<sup>2</sup> = 0.417; <i>p</i> = 0.0001), IL − 6 (ƞp2 = 0.085; <i>p</i> = 0.015), IL − 1b (ƞp<sup>2</sup> = 0.058; <i>p</i> = 0.037), and Inflam z-score 5 (ƞp<sup>2</sup> = 0.059, <i>p</i> = 0.004). Moderation analysis demonstrated that the inflammatory score at baseline was a significant predictor of the effect of the intervention on the CRP levels. Anthocyanin supplementation reduces CRP and cardiovascular disease biomarkers in individuals at risk of dementia, especially when there is increased inflammation at baseline. ClinicalTrials.gov study identifier: NCT03419039.</p>

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Anthocyanin supplementation in adults at risk for dementia: a randomized controlled trial on its cardiometabolic and anti-inflammatory biomarker effects

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月2日

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  • Miguel German Borda,
  • Robinson Ramírez-Vélez,
  • Felipe Botero-Rodriguez,
  • Jonathan Patricio-Baldera,
  • Chiara de Lucia,
  • Ilaria Pola,
  • George E. Barreto,
  • Khadija Khalifa,
  • Anne Katrine Bergland,
  • Miia Kivipelto,
  • Tommy Cederholm,
  • Henrik Zetterberg,
  • Nicholas J. Ashton,
  • Clive Ballard,
  • Richard Siow,
  • Dag Aarsland,
  • Jenni Lehtisalo,
  • Tiia Ngandu,
  • Yujiro Kuroda,
  • Arai Hidenori,
  • Francesca Mangialasche,
  • Taiki Sugimoto,
  • Kazuaki Uchida,
  • Kosuke Fujita,
  • Ingelin Testad,
  • Martha Therese Gjestsen

摘要

Anthocyanins are dietary flavonoids shown to have a therapeutic capacity to mitigate inflammation and oxidative stress. The present secondary analyses from the “Anthocyanins in People at Risk for Dementia Study” were aimed at (I) determining the intervention’s effect on blood-based markers of cardiovascular disease and inflammation and (II) evaluating whether baseline factors such as age, sex, inflammation, or cardiometabolic score may moderate the intervention’s effect on inflammatory status. This study was an ancillary, 24-week randomized, double-blind, placebo-controlled Phase II trial. Sub-sample participants (n = 99), aged 60–80 years with mild cognitive impairment or cardiometabolic disorders, were randomized to receive either 320 mg/day of anthocyanins or placebo. The biomarkers analyzed included inflammatory biomarker assessment (IL − 6, IL − 8, IL − 10, IL − 1b, TNF − α, IFN − γ), and C-reactive protein (CRP), as well as albumin, thrombocytes, cholesterol, LDL, HDL, and triglycerides, which were longitudinally compared between both groups. Baseline characteristics were balanced between the groups. ANCOVA analyses reveal 24-week differences favoring the anthocyanin treatment in LDL cholesterol levels (ƞp2 = 0.078; p = 0.015), cardiometabolic score (ƞp2 = 0.073; p = 0.021), CRP levels (ƞp2 = 0.417; p = 0.0001), IL − 6 (ƞp2 = 0.085; p = 0.015), IL − 1b (ƞp2 = 0.058; p = 0.037), and Inflam z-score 5 (ƞp2 = 0.059, p = 0.004). Moderation analysis demonstrated that the inflammatory score at baseline was a significant predictor of the effect of the intervention on the CRP levels. Anthocyanin supplementation reduces CRP and cardiovascular disease biomarkers in individuals at risk of dementia, especially when there is increased inflammation at baseline. ClinicalTrials.gov study identifier: NCT03419039.