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<p>This randomized controlled trial compared the effects of home-based exercise, with or without cognitive training, on cognition and physical function in individuals aged 50&#xa0;years and older with stable CVD during the COVID-19 pandemic. 122 patients (67.3 ± 7.9&#xa0;years, 71% men) with stable CVD (77% coronary heart disease) were randomly assigned (1:1) to (1) Home-based physical exercise alone, or (2) Home-based physical exercise combined with cognitive training. Cognition (executive functions (primary outcome), processing speed, episodic memory, and working memory) and physical functions were assessed remotely at baseline, 3&#xa0;months, and 6&#xa0;months. Adjusted mean changes from baseline to 3&#xa0;months and 6&#xa0;months for executive functions, episodic memory, working memory, sit-to-stand test, gait speed, and timed up-and-go test were significant in the overall sample (<i>p</i> &lt; 0.05). Furthermore, executive functions, episodic memory, sit-to-stand test, and timed up-and-go performances were significantly improved at 6&#xa0;months in both groups when analyzed separately although no group differences were observed. Mean exercise dose differed significantly between the 2 groups: 1413 vs 953 METs.min<sup>−1</sup>&#xa0;week<sup>−1</sup> respectively for the exercise and combined group (<i>p</i> &lt; 0.01). Mean cognitive training duration was 25.6 ± 16.6&#xa0;min.week<sup>−1</sup> for the combined intervention group. Results remained unchanged after accounting for the exercise dose. In adults affected by CVD, a remote combined intervention integrating sequential cognitive and exercise training yields comparable enhancements in executive function, episodic memory, and physical performances compared to exercise training alone. ClinicalTrials.gov: NCT04661189.</p> Graphical abstract <p></p>

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Effects of home-based exercise with or without cognitive training on cognition and mobility in cardiac patients: A randomized clinical trial

  • 期刊论文

  • 发表日期：

    2025年2月3日

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  • Florent Besnier,
  • Emma Gabrielle Dupuy,
  • Christine Gagnon,
  • Thomas Vincent,
  • Tudor Vrinceanu,
  • Caroll-Ann Blanchette,
  • Josep Iglesies-Grau,
  • Kathia Saillant,
  • Malorie Chabot-Blanchet,
  • Sylvie Belleville,
  • Martin Juneau,
  • Paolo Vitali,
  • Mathieu Gayda,
  • Anil Nigam,
  • Louis Bherer

摘要

This randomized controlled trial compared the effects of home-based exercise, with or without cognitive training, on cognition and physical function in individuals aged 50 years and older with stable CVD during the COVID-19 pandemic. 122 patients (67.3 ± 7.9 years, 71% men) with stable CVD (77% coronary heart disease) were randomly assigned (1:1) to (1) Home-based physical exercise alone, or (2) Home-based physical exercise combined with cognitive training. Cognition (executive functions (primary outcome), processing speed, episodic memory, and working memory) and physical functions were assessed remotely at baseline, 3 months, and 6 months. Adjusted mean changes from baseline to 3 months and 6 months for executive functions, episodic memory, working memory, sit-to-stand test, gait speed, and timed up-and-go test were significant in the overall sample (p < 0.05). Furthermore, executive functions, episodic memory, sit-to-stand test, and timed up-and-go performances were significantly improved at 6 months in both groups when analyzed separately although no group differences were observed. Mean exercise dose differed significantly between the 2 groups: 1413 vs 953 METs.min−1 week−1 respectively for the exercise and combined group (p < 0.01). Mean cognitive training duration was 25.6 ± 16.6 min.week−1 for the combined intervention group. Results remained unchanged after accounting for the exercise dose. In adults affected by CVD, a remote combined intervention integrating sequential cognitive and exercise training yields comparable enhancements in executive function, episodic memory, and physical performances compared to exercise training alone. ClinicalTrials.gov: NCT04661189.

Graphical abstract